ArticlePlant physiology2016
AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 101 citations in OpenAlex.
- AtKC1 inhibits AKT1 activation via its amino-terminal inhibitory domain.Plant communications · 2025Article
- Review
- Transcriptome analysis and identification of the low potassium stress-responsive gene SiSnRK2.6 in foxtail millet (Setaria italica L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Comparative physiological and transcriptome analysis between potassium-deficiency tolerant and sensitive sweetpotato genotypes in response to potassium-deficiency stress.BMC genomics · 2024Article
- Genome-wide identification of Shaker KFrontiers in plant science · 2024Article
- Living with high potassium: Balance between nutrient acquisition and K-induced salt stress signaling.Plant physiology · 2023Article
- Unfolding molecular switches for salt stress resilience in soybean: recent advances and prospects for salt-tolerant smart plant production.Frontiers in plant science · 2023Review
- Regulation of Macrophage Polarization by miR-449a/Cripto-1-PI3K/AKT/NF-BioMed research international · 2023Article
- Does Potassium (KInternational journal of molecular sciences · 2022Review
- Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.Nature communications · 2022Article
- PPVED: A machine learning tool for predicting the effect of single amino acid substitution on protein function in plants.Plant biotechnology journal · 2022Article
- Genome-Wide Identification of the Salvia miltiorrhiza SmCIPK Gene Family and Revealing the Salt Resistance Characteristic of SmCIPK13International journal of molecular sciences · 2022Article
- Non-autonomous stomatal control by pavement cell turgor via the K+ channel subunit AtKC1.The Plant cell · 2022Article
- Primary nutrient sensors in plants.iScience · 2022Review
- Comparative Physiological and Transcriptome Profiles Uncover Salt Tolerance Mechanisms in Alfalfa.Frontiers in plant science · 2022Article
- Identification, expression, and association analysis of calcineurin B-like protein-interacting protein kinase genes in peanut.Frontiers in genetics · 2022Article
- Genome Editing Targets for Improving Nutrient Use Efficiency and Nutrient Stress Adaptation.Frontiers in genetics · 2022Review
- Delineating Calcium Signaling Machinery in Plants: Tapping the Potential through Functional Genomics.Current genomics · 2021Review
- The Complex Story of Plant Cyclic Nucleotide-Gated Channels.International journal of molecular sciences · 2021Review
- The CaFrontiers in plant science · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Arabidopsis (Arabidopsis thaliana), the Shaker K(+) channel AKT1 conducts K(+) uptake in root cells, and its activity is regulated by CBL1/9-CIPK23 complexes as well as by the AtKC1 channel subunit. CIPK23 and AtKC1 are both involved in the AKT1-mediated low-K(+) (LK) response; however, the relationship between them remains unclear. In this study, we screened suppressors of low-K(+) sensitive [lks1 (cipk23)] and isolated the suppressor of lks1 (sls1) mutant, which suppressed the leaf chlorosis phenotype of lks1 under LK conditions. Map-based cloning revealed a point mutation in AtKC1 of sls1 that led to an amino acid substitution (G322D) in the S6 region of AtKC1. The G322D substitution generated a gain-of-function mutation, AtKC1(D), that enhanced K(+) uptake capacity and LK tolerance in Arabidopsis. Structural prediction suggested that glycine-322 is highly conserved in K(+) channels and may function as the gating hinge of plant Shaker K(+) channels. Electrophysiological analyses revealed that, compared with wild-type AtKC1, AtKC1(D) showed enhanced inhibition of AKT1 activity and strongly reduced K(+) leakage through AKT1 under LK conditions. In addition, phenotype analysis revealed distinct phenotypes of lks1 and atkc1 mutants in different LK assays, but the lks1 atkc1 double mutant always showed a LK-sensitive phenotype similar to that of akt1 This study revealed a link between CIPK-mediated activation and AtKC1-mediated modification in AKT1 regulation. CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated LK responses in Arabidopsis.
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