ReviewThe Journal of clinical investigation2016
In vivo platforms for analysis of HIV persistence and eradication.
Review in The Journal of clinical investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Unique molecular signatures in rebound viruses from antiretroviral drug and CRISPR-treated HIV-1-infected humanized mice.Communications biology · 2025Article
- Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice.iScience · 2024Article
- So Pathogenic or So What?-A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research.Viruses · 2022Review
- Human Hematopoietic Stem Cell (HSC)-Engrafted NSG Mice for HIV Latency Research.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody.Scientific reports · 2021Article
- Review
- Review
- Pathogenic Role of Type I Interferons in HIV-Induced Immune Impairments in Humanized Mice.Current HIV/AIDS reports · 2019Review
- T cells establish and maintain CNS viral infection in HIV-infected humanized mice.The Journal of clinical investigation · 2018Article
- Humanized Mice Engrafted With Human HSC Only or HSC and Thymus Support Comparable HIV-1 Replication, Immunopathology, and Responses to ART and Immune Therapy.Frontiers in immunology · 2018Article
- In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.Cell reports · 2017Article
- Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa.JCI insight · 2017Article
- Exploring the Immunopathogenesis of Viral Hemorrhagic Fever in Mice with a Humanized Immune System.Frontiers in immunology · 2017Review
- Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy.Stem cells and development · 2016Article
- Humanized mice for HIV and AIDS research.Current opinion in virology · 2016Review
- Latency reversal and viral clearance to cure HIV-1.Science (New York, N.Y.) · 2016Review
- Animal models to achieve an HIV cure.Current opinion in HIV and AIDS · 2016Review
- Recent developments in the effort to cure HIV infection: going beyond N = 1.The Journal of clinical investigation · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
HIV persistence in patients undergoing antiretroviral therapy is a major impediment to the cure of HIV/AIDS. The molecular and cellular mechanisms underlying HIV persistence in vivo have not been fully elucidated. This lack of basic knowledge has hindered progress in this area. The in vivo analysis of HIV persistence and the implementation of curative strategies would benefit from animal models that accurately recapitulate key aspects of the human condition. This Review summarizes the contribution that humanized mouse models of HIV infection have made to the field of HIV cure research. Even though these models have been shown to be highly informative in many specific areas, their great potential to serve as excellent platforms for discovery in HIV pathogenesis and treatment has yet to be fully developed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.