ArticlePLoS computational biology2016
Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Synergistic interactions in designed bacterial consortia: Dual effects on control rusty root rot and growth promotion in ginseng.Synthetic and systems biotechnology · 2026Article
- Living circuit boards built by printing bacterial transistors.Nature chemical biology · 2026Article
- Genetic designs for stochastic and probabilistic biocomputing.Physical review. E · 2025Article
- Review
- Partitioning of a 2-bit hash function across 66 communicating cells.Nature chemical biology · 2025Article
- Open problems in synthetic multicellularity.NPJ systems biology and applications · 2024Article
- Emergent digital bio-computation through spatial diffusion and engineered bacteria.Nature communications · 2024Article
- Open-endedness in synthetic biology: A route to continual innovation for biological design.Science advances · 2024Review
- Coupling Cell Communication and Optogenetics: Implementation of a Light-Inducible Intercellular System in Yeast.ACS synthetic biology · 2023Article
- Article
- Implementing re-configurable biological computation with distributed multicellular consortia.Nucleic acids research · 2022Article
- Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback.Nature communications · 2022Article
- Engineering microbial consortia with rationally designed cellular interactions.Current opinion in biotechnology · 2022Review
- Design and Use of a Gold Nanoparticle-Carbon Dot Hybrid for a FLIM-Based IMPLICATION Nano Logic Gate.ACS omega · 2022Article
- NOT Gates Based on Protein Degradation as a Case Study for a New Modular Modeling via SBML Level 3-Comp Package.Frontiers in bioengineering and biotechnology · 2022Article
- Engineered microbial consortia: strategies and applications.Microbial cell factories · 2021Review
- Emerging Molecular Tools for Engineering Phytomicrobiome.Indian journal of microbiology · 2021Review
- Directed Evolution of Microbial Communities.Annual review of biophysics · 2021Review
- 2D printed multicellular devices performing digital and analogue computation.Nature communications · 2021Article
- Contextual dependencies expand the re-usability of genetic inverters.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Engineered synthetic biological devices have been designed to perform a variety of functions from sensing molecules and bioremediation to energy production and biomedicine. Notwithstanding, a major limitation of in vivo circuit implementation is the constraint associated to the use of standard methodologies for circuit design. Thus, future success of these devices depends on obtaining circuits with scalable complexity and reusable parts. Here we show how to build complex computational devices using multicellular consortia and space as key computational elements. This spatial modular design grants scalability since its general architecture is independent of the circuit's complexity, minimizes wiring requirements and allows component reusability with minimal genetic engineering. The potential use of this approach is demonstrated by implementation of complex logical functions with up to six inputs, thus demonstrating the scalability and flexibility of this method. The potential implications of our results are outlined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.