Trial reportHead & neck2016
Intraoperative goal-directed hemodynamic management in free tissue transfer for head and neck cancer.
Trial report in Head & neck, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03799250 (Common Clinical Indices-guided Bolus-based vs. Continuous Fluid Management A Prospective, Randomized Trial), which is not on this map. Cited by 16 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Common Clinical Indices-guided Bolus-based vs. Continuous Fluid Management A Prospective, Randomized Trial
Who cites it
16 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Perioperative Goal Directed Versus Conventional Fluid Therapy in Head and Neck Free Flap Surgery:Sultan Qaboos University medical journal · 2025Pooled it
- Goal-directed therapy guided by the FloTrac sensor in major surgery: a systematic review and meta-analysis.Critical care science · 2024Pooled it
- Goal-directed haemodynamic therapy during general anaesthesia for noncardiac surgery: a systematic review and meta-analysis.British journal of anaesthesia · 2022Pooled it
- Perioperative restrictive versus goal-directed fluid therapy for adults undergoing major non-cardiac surgery.The Cochrane database of systematic reviews · 2019Pooled it
- Is goal-directed fluid therapy based on dynamic variables alone sufficient to improve clinical outcomes among patients undergoing surgery? A meta-analysis.Critical care (London, England) · 2018Pooled it
- Association of conflicts of interest with the results and conclusions of goal-directed hemodynamic therapy research: a systematic review with meta-analysis.Intensive care medicine · 2018Pooled it
- Effects of perioperative goal-directed fluid therapy combined with the application of alpha-1 adrenergic agonists on postoperative outcomes: a systematic review and meta-analysis.BMC anesthesiology · 2018Pooled it
- Comparison of Stroke Volume Variation-based goal-directed Therapy Versus Standard Fluid Therapy in Patients Undergoing Head and Neck Surgery: A Randomized Controlled StudyBalkan medical journal · 2022Trial
- Intraoperative vasopressors in head and neck free flap reconstruction.Microsurgery · 2021Trial
- Perioperative goal-directed minimally invasive hemodynamic therapy in surgery: a systematic review and meta-analysis.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Impact of goal-directed hemodynamic therapy on perioperative outcomes in head and neck free flap surgery: A before-and-after pilot study.Health science reports · 2024Article
- Intraoperative goal-directed fluid therapy in neurosurgical patients: A systematic review.Surgical neurology international · 2024Review
- Review
- Perioperative predictors of early surgical revision and flap-related complications after microvascular free tissue transfer in head and neck reconstructions: a retrospective observational series.Clinical oral investigations · 2021Observational
- Article
- Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial.Annals of intensive care · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundThe purpose of this study was to determine the effect of algorithmic physiologic management on patients undergoing head and neck free tissue transfer and reconstruction.
methodsNinety-four adult patients were randomized to treatment and control groups. The blood pressure of the control group was managed consistent with contemporary standards. The treatment group was managed using an algorithm based on blood pressure and calculated physiologic values derived from arterial waveform analysis. Primary outcome was intensive care unit (ICU) length of stay.
resultsICU length of stay was decreased in the treatment group (33.7 vs 58.3 hours; p = .026). The complication rate was not increased in the treatment group.
conclusionThe goal-directed hemodynamic management algorithm decreased the ICU length of stay. Judicious use of vasoactive drugs and goal-directed fluid administration has a role in improving perioperative outcomes for patients undergoing head and neck free tissue transfer. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1974-E1980, 2016.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.