ArticleFood & nutrition research2016
Effects of maternal mild zinc deficiency and different ways of zinc supplementation for offspring on learning and memory.
Article in Food & nutrition research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Effect of Zinc Status on Pubertal and Cognitive Functions in Male Offspring of Rats with Induced Zinc Deficiency During Gestation and Lactation.Biological trace element research · 2026Article
- Marginal Zinc Deficiency during Gestation and Lactation in Rats Affects Oligodendrogenesis, Motor Performance, and Behavior in the Offspring.The Journal of nutrition · 2023Article
- The Important Role of Zinc in Neurological Diseases.Biomolecules · 2022Review
- Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation.Biological trace element research · 2021Article
- Neurobiology of zinc and its role in neurogenesis.European journal of nutrition · 2021Review
- Effects of Maternal Prenatal Multi-Micronutrient Supplementation on Growth and Development until 3 Years of Age.International journal of environmental research and public health · 2019Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundThe effect of different ways of zinc supplementation on spatial learning and memory remains unclear.
objectivesThis study aims to assess the effectiveness of two ways of zinc supplementation - oral use and intravenous transfusion - in zinc-deficient offspring rats on learning and memory.
designRats were randomly divided into six groups on the first day of pregnancy (n=12): control (CO), pair fed (PF), zinc deprived (ZD), oral zinc supplementation (OZS), injection zinc supplementation (IZS), and injection control. The offspring's spatial learning and memory were tested at postnatal day 35 using Morris water maze (MWM). Maternal rats' serum zinc was measured at postnatal day 21, while pups' serum zinc was measured at postnatal day 35.
resultsCompared with the CO and PF groups, pups in ZD group spent more time finding the latent platform and swam longer distances (p<0.05). Compared with ZD groups, pups in OZS group significantly decreased the time used for finding the platform and the swimming distance (p<0.05) and were similar to that of CO and PF groups (p>0.05). However, compared with ZD groups, pups in IZS did not show any improvement in the indexes of MWM (p>0.05) although their zinc serum concentration increased significantly (p<0.05).
conclusionsThese results indicate that mild zinc deficiency during pregnancy and lactation leads to the impairment of learning and memory function in offspring, and that OZS, instead of intravenous transfusion zinc supplementation, can recover the impairment of spatial learning and memory function.
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