ArticleEpidemiology (Cambridge, Mass.)2016
The LEGACY Girls Study: Growth and Development in the Context of Breast Cancer Family History.
Article in Epidemiology (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Impact of Genetic Testing for Cardiomyopathy on Emotional Well-Being and Family Dynamics: A Study of Parents and Adolescents.Circulation. Genomic and precision medicine · 2021Trial
- Steroids, stress, and body mass index interact to accelerate female pubertal development.The Journal of clinical endocrinology and metabolism · 2026Article
- Timing of puberty in girls and serum polycyclic aromatic hydrocarbon (PAH)-albumin adduct levels: the California PAH Study.Journal of exposure science & environmental epidemiology · 2025Article
- Childhood physical activity and pubertal timing: findings from the LEGACY girls study.International journal of epidemiology · 2024Article
- Urinary Androgens Provide Additional Evidence Related to Metabolism and Are Correlated With Serum Androgens in Girls.Journal of the Endocrine Society · 2024Article
- Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk.International journal of epidemiology · 2023Article
- Body mass index rebound and pubertal timing in girls with and without a family history of breast cancer: the LEGACY girls study.International journal of epidemiology · 2022Article
- Predictors of urinary polycyclic aromatic hydrocarbon metabolites in girls from the San Francisco Bay Area.Environmental research · 2022Article
- Improvement on recovery and reproducibility for quantifying urinary mono-hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs).Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2022Article
- Common Childhood Viruses and Pubertal Timing: The LEGACY Girls Study.American journal of epidemiology · 2021Article
- Mothers' Diet and Family Income Predict Daughters' Healthy Eating.Preventing chronic disease · 2021Article
- Prepubertal Internalizing Symptoms and Timing of Puberty Onset in Girls.American journal of epidemiology · 2021Article
- Influence of pubertal development on urinary oxidative stress biomarkers in adolescent girls in the New York LEGACY cohort.Free radical research · 2020Article
- Association of Prepubertal and Adolescent Androgen Concentrations With Timing of Breast Development and Family History of Breast Cancer.JAMA network open · 2019Article
- Comparison of methods to assess onset of breast development in the LEGACY Girls Study: methodological considerations for studies of breast cancer.Breast cancer research : BCR · 2018Article
- Breast cancer family history and allele-specific DNA methylation in the legacy girls study.Epigenetics · 2018Article
- Pubertal development in girls by breast cancer family history: the LEGACY girls cohort.Breast cancer research : BCR · 2017Article
- Non-invasive optical spectroscopic monitoring of breast development during puberty.Breast cancer research : BCR · 2017Article
- Article
- Comparison of Clinical, Maternal, and Self Pubertal Assessments: Implications for Health Studies.Pediatrics · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundAlthough the timing of pubertal milestones has been associated with breast cancer risk, few studies of girls' development include girls at increased breast cancer risk due to their family history.
methodsThe Lessons in Epidemiology and Genetics of Adult Cancer from Youth (LEGACY) Girls Study was initiated in 2011 in the USA and Canada to assess the relation between early life exposures and intermediate markers of breast cancer risk (e.g., pubertal development, breast tissue characteristics) and to investigate psychosocial well being and health behaviors in the context of family history. We describe the methods used to establish and follow a cohort of 1,040 girls ages 6-13 years at baseline, half with a breast cancer family history, and the collection of questionnaire data (family history, early life exposures, growth and development, psychosocial and behavioral), anthropometry, biospecimens, and breast tissue characteristics using optical spectroscopy.
resultsDuring this initial 5-year phase of the study, follow-up visits are conducted every 6 months for repeated data and biospecimen collection. Participation in baseline components was high (98% for urine, 97.5% for blood or saliva, and 98% for anthropometry). At enrollment, 77% of girls were premenarcheal and 49% were at breast Tanner stage T1.
conclusionsThis study design allows thorough examination of events affecting girls' growth and development and how they differ across the spectrum of breast cancer risk. A better understanding of early life breast cancer risk factors will be essential to enhance prevention across the lifespan for those with and without a family history of the disease.
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