ReviewAmerican journal of physical medicine & rehabilitation2016
Combining Dopaminergic Facilitation with Robot-Assisted Upper Limb Therapy in Stroke Survivors: A Focused Review.
Review in American journal of physical medicine & rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of task-oriented training assisted by force feedback hand rehabilitation robot on finger grasping function in stroke patients with hemiplegia: a randomised controlled trial.Journal of neuroengineering and rehabilitation · 2024Trial
- Commercial head-mounted display virtual reality for upper extremity rehabilitation in chronic stroke: a single-case design study.Journal of neuroengineering and rehabilitation · 2020Trial
- The effects of video game therapy on balance and attention in chronic ambulatory traumatic brain injury: an exploratory study.BMC neurology · 2017Trial
- Overview of the role of robots in upper limb disabilities rehabilitation: a scoping review.Archives of public health = Archives belges de sante publique · 2023Article
- The role of ventral tegmental area in chronic stroke rehabilitation: an exploratory study.Frontiers in neurology · 2023Article
- Article
- Wearable Immersive Virtual Reality Device for Promoting Physical Activity in Parkinson's Disease Patients.Sensors (Basel, Switzerland) · 2022Article
- The effects of continuous oromotor activity on speech motor learning: speech biomechanics and neurophysiologic correlates.Experimental brain research · 2021Article
- Predicting and Monitoring Upper-Limb Rehabilitation Outcomes Using Clinical and Wearable Sensor Data in Brain Injury Survivors.IEEE transactions on bio-medical engineering · 2021Article
- Enabling precision rehabilitation interventions using wearable sensors and machine learning to track motor recovery.NPJ digital medicine · 2020Article
- Neurotechnology-aided interventions for upper limb motor rehabilitation in severe chronic stroke.Brain : a journal of neurology · 2019Review
- The Intersection of Central Dopamine System and Stroke: Potential Avenues Aiming at Enhancement of Motor Recovery.Frontiers in synaptic neuroscience · 2018Review
- Article
- Article
- Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research.Progress in neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Despite aggressive conventional therapy, lasting hemiplegia persists in a large percentage of stroke survivors. The aim of this article is to critically review the rationale behind targeting multiple sites along the motor learning network by combining robotic therapy with pharmacotherapy and virtual reality-based reward learning to alleviate upper extremity impairment in stroke survivors. Methods for personalizing pharmacologic facilitation to each individual's unique biology are also reviewed. At the molecular level, treatment with levodopa was shown to induce long-term potentiation-like and practice-dependent plasticity. Clinically, trials combining conventional therapy with levodopa in stroke survivors yielded statistically significant but clinically unconvincing outcomes because of limited personalization, standardization, and reproducibility. Robotic therapy can induce neuroplasticity by delivering intensive, reproducible, and functionally meaningful interventions that are objective enough for the rigors of research. Robotic therapy also provides an apt platform for virtual reality, which boosts learning by engaging reward circuits. The future of stroke rehabilitation should target distinct molecular, synaptic, and cortical sites through personalized multimodal treatments to maximize motor recovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.