Evidence map›Paper›PMID 26829030›Full record

ArticleThe Journal of investigative dermatology2016

Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma.

Maryam M Asgari, Wei Wang, Nilah M Ioannidis, Jacqueline Itnyre, Thomas Hoffmann, Eric Jorgenson, Alice S Whittemore

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 9 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 9 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Maryam M AsgariDepartment of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Wei WangDepartment of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA.
Nilah M IoannidisDepartment of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Jacqueline ItnyreDepartment of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA.
Thomas HoffmannDepartment of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, California, USA.
Eric JorgensonDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Alice S WhittemoreDepartment of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA. Electronic address: alicesw@stanford.edu.
Stanford University · USKaiser Permanente · USMassachusetts General Hospital · USUniversity of California, San Francisco · US

Funding

A Resource for Genetic Epidemiology Research in Adult Health and AgingRC2AG036607 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI RISCH, NEIL J., SCHAEFER, CATHERINE ANN · 2009 to 2010
$24.8M
Statistical Methods for Genetic EpidemiologyR01CA094069 · NCI · STANFORD UNIVERSITY · PI WHITTEMORE, ALICE · 2002 to 2016
$7.7M
Genome-wide association study of cutaneous squamous cell carincomaR01CA166672 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ASGARI, MARYAM MANDANA · 2013 to 2016
$1.3M
NCI NIH HHS R01 CA094069NCI NIH HHS R01 CA166672NIA NIH HHS RC2 AG036607
6 · The paper itself

Abstract

We report a genome-wide association study of cutaneous squamous cell carcinoma conducted among non-Hispanic white members of the Kaiser Permanente Northern California health care system. The study includes a genome-wide screen of 61,457 members (6,891 cases and 54,566 controls) genotyped on the Affymetrix Axiom European array and a replication phase involving an independent set of 6,410 additional members (810 cases and 5,600 controls). Combined analysis of screening and replication phases identified 10 loci containing single-nucleotide polymorphisms (SNPs) with P-values < 5 × 10(-8). Six loci contain genes in the pigmentation pathway; SNPs at these loci appear to modulate squamous cell carcinoma risk independently of the pigmentation phenotypes. Another locus contains HLA class II genes studied in relation to elevated squamous cell carcinoma risk following immunosuppression. SNPs at the remaining three loci include an intronic SNP in FOXP1 at locus 3p13, an intergenic SNP at 3q28 near TP63, and an intergenic SNP at 9p22 near BNC2. These findings provide insights into the genetic factors accounting for inherited squamous cell carcinoma susceptibility.

Indexed as

Genetic LociGenome-Wide Association StudyAdultCaliforniaCarcinoma, Squamous CellCase-Control StudiesCohort StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideSkin NeoplasmsWhite People

Identifiers

PMID26829030
PMCPMC4842155
OpenAlexW2291006557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.