ArticleNature structural & molecular biology2016
Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters.
Article in Nature structural & molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed.
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- Architecture and autoinhibitory mechanism of the plasma membrane NaNature communications · 2023Article
- Biological fractionation of lithium isotopes by cellular NaiScience · 2023Article
- Crystal structure of the NaNature communications · 2022Article
- Article
6 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
To fully understand the transport mechanism of Na(+)/H(+) exchangers, it is necessary to clearly establish the global rearrangements required to facilitate ion translocation. Currently, two different transport models have been proposed. Some reports have suggested that structural isomerization is achieved through large elevator-like rearrangements similar to those seen in the structurally unrelated sodium-coupled glutamate-transporter homolog GltPh. Others have proposed that only small domain movements are required for ion exchange, and a conventional rocking-bundle model has been proposed instead. Here, to resolve these differences, we report atomic-resolution structures of the same Na(+)/H(+) antiporter (NapA from Thermus thermophilus) in both outward- and inward-facing conformations. These data combined with cross-linking, molecular dynamics simulations and isothermal calorimetry suggest that Na(+)/H(+) antiporters provide alternating access to the ion-binding site by using elevator-like structural transitions.
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