ArticlePloS one2016
Unraveling the Tissue-Specific Gene Signatures of Gilthead Sea Bream (Sparus aurata L.) after Hyper- and Hypo-Osmotic Challenges.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Mild oxidative stress and dietary epigenetic modulators direct DNA methylation remodeling toward stress-resilience pathways.BMC genomics · 2026Article
- Distinct Gene Expression Patterns Reveal the Acclimatization Strategies To High-Salinity Stress in Gills of Mozambique Tilapia (Oreochromis mossambicus).Marine biotechnology (New York, N.Y.) · 2026Article
- Gilthead Seabream Liver Integrative Proteomics and Metabolomics Analysis Reveals Regulation by Different Prosurvival Pathways in the Metabolic Adaptation to Stress.International journal of molecular sciences · 2022Article
- Osmoregulatory Plasticity of Juvenile Greater Amberjack (Animals : an open access journal from MDPI · 2021Article
- Aflatoxicosis Dysregulates the Physiological Responses to Crowding Densities in the Marine Teleost Gilthead Seabream (Animals : an open access journal from MDPI · 2021Article
- Draft genome assembly of Tenualosa ilisha, Hilsa shad, provides resource for osmoregulation studies.Scientific reports · 2019Article
- Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes.Frontiers in endocrinology · 2018Review
- Brain Transcriptome Profiling Analysis of Nile Tilapia (Frontiers in physiology · 2018Article
- Impact of Air Exposure on Vasotocinergic and Isotocinergic Systems in Gilthead Sea Bream (Frontiers in physiology · 2018Article
- Salinity Effects on Strategies of Glycogen Utilization in Livers of Euryhaline Milkfish (Frontiers in physiology · 2018Article
- The circadian transcriptome of marine fish (Sparus aurata) larvae reveals highly synchronized biological processes at the whole organism level.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A custom microarray was used for the transcriptomic profiling of liver, gills and hypothalamus in response to hypo- (38‰ → 5‰) or hyper- (38‰ → 55‰) osmotic challenges (7 days after salinity transfer) in gilthead sea bream (Sparus aurata) juveniles. The total number of differentially expressed genes was 777. Among them, 341 and 310 were differentially expressed in liver after hypo- and hyper-osmotic challenges, respectively. The magnitude of changes was lower in gills and hypothalamus with around 131 and 160 responsive genes in at least one osmotic stress condition, respectively. Regardless of tissue, a number of genes were equally regulated in either hypo- and hyper-osmotic challenges: 127 out of 524 in liver, 11 out of 131 in gills and 19 out of 160 in hypothalamus. In liver and gills, functional analysis of differentially expressed genes recognized two major clusters of overlapping canonical pathways that were mostly related to "Energy Metabolism" and "Oxidative Stress". The later cluster was represented in all the analyzed tissues, including the hypothalamus, where differentially expressed genes related to "Cell and tissue architecture" were also over-represented. Overall the response for "Energy Metabolism" was the up-regulation, whereas for oxidative stress-related genes the type of response was highly dependent of tissue. These results support common and different osmoregulatory responses in the three analyzed tissues, helping to load new allostatic conditions or even to return to basal levels after hypo- or hyper-osmotic challenges according to the different physiological role of each tissue.
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