Evidence map›Paper›PMID 26828742›Full record

ReviewThe American journal of pathology2016

Biological Processes Discovered by High-Throughput Sequencing.

Brian J Reon, Anindya Dutta

Abstract readReview
In one paragraph

Review in The American journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Extrachromosomal Circular DNA (eccDNA): From Chaos to Function.Frontiers in cell and developmental biology · 2021
    Review
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brian J ReonDepartment of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia.
Anindya DuttaDepartment of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address: ad8q@virginia.edu.

Funding

VEGF, FAK and RAPP01CA104106 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PASCHAL, BRYCE, THEODORESCU, DAN · 2005 to 2015
$17.9M
Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4M
The role of MCM8-9 in genomic instability of cancersR01CA060499 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Anindya Dutta · 1994 to 2026
$8.6M
Regulation of TIP60 by the ubiquitin-proteasome pathwayR01GM084465 · NIGMS · UNIVERSITY OF VIRGINIA · PI DUTTA, ANINDYA · 2008 to 2017
$2.4M
Effect of anti-S phase agents on human chromosomesR01CA166054 · NCI · UNIVERSITY OF VIRGINIA · PI DUTTA, ANINDYA · 2013 to 2017
$1.6M
NCI NIH HHS P01 CA104106NCI NIH HHS R01 CA060499NCI NIH HHS R01 CA166054NCI NIH HHS R01 CA60499NCI NIH HHS T32 CA009109NIGMS NIH HHS R01 GM084465NIGMS NIH HHS T32 GM007267
6 · The paper itself

Abstract

Advances in DNA and RNA sequencing technologies have completely transformed the field of genomics. High-throughput sequencing (HTS) is now a widely used and accessible technology that allows scientists to sequence an entire transcriptome or genome in a timely and cost-effective manner. Application of HTS techniques has led to many key discoveries, including the identification of long noncoding RNAs, microDNAs, a family of small extrachromosomal circular DNA species, and tRNA-derived fragments, which are a group of small non-miRNAs that are derived from tRNAs. Furthermore, public sequencing repositories provide unique opportunities for laboratories to parse large sequencing databases to identify proteins and noncoding RNAs at a scale that was not possible a decade ago. Herein, we review how HTS has led to the discovery of novel nucleic acid species and uncovered new biological processes during the course.

Indexed as

High-Throughput Nucleotide SequencingSequence Analysis, DNASequence Analysis, RNAAnimalsBiological PhenomenaGenomicsHumansTranscriptome

Identifiers

PMID26828742
PMCPMC5807928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.