Evidence map›Paper›PMID 26828710›Full record

Trial reportThe Journal of head trauma rehabilitation

Duration of Posttraumatic Amnesia Predicts Neuropsychological and Global Outcome in Complicated Mild Traumatic Brain Injury.

Tessa Hart, Thomas A Novack, Nancy Temkin, Jason Barber, Sureyya S Dikmen, Ramon Diaz-Arrastia, Joseph Ricker, Dale C Hesdorffer, Jack Jallo, Nancy H Hsu and 1 more

Open access · greenAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in The Journal of head trauma rehabilitation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Tessa HartMoss Rehabilitation Research Institute, Elkins Park, Pennsylvania (Dr Hart); Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham (Dr Novack); Neurological Surgery and Biostatistics (Dr Temkin), Neurological Surgery (Mr Barber), Department of Rehabilitation Medicine, (Dr Dikmen), University of Washington, Seattle; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland (Dr Diaz-Arrastia); Department of Rehabilitation Medicine, NYU School of Medicine, New York (Dr Ricker); GH Sergievsky Center and Department of Epidemiology, Columbia University, New York (Dr Hesdorffer); Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania (Dr Jallo); Department of Physical Medicine & Rehabilitation, Virginia Commonwealth University, Richmond, Virginia (Dr Hsu); and Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston (Dr Zafonte).
Thomas A Novack
Nancy Temkin
Jason Barber
Sureyya S Dikmen
Ramon Diaz-Arrastia
Joseph Ricker
Dale C Hesdorffer
Jack Jallo
Nancy H Hsu
Ross Zafonte
Seattle University · USUniformed Services University of the Health Sciences · US

Funding

Traumatic Brain Injury Clinical Trials NetworkU01HD042738 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI LOFTUS, CHRISTOPHER · 2002 to 2010
$2.0M
Traumatic Brain Injury Clinical Trials NetworkU01HD042687 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NOVACK, THOMAS · 2002 to 2010
$1.9M
NICHD NIH HHS U01 HD042687NICHD NIH HHS U01 HD042738
6 · The paper itself

Abstract

objectivesExamine the effects of posttraumatic amnesia (PTA) duration on neuropsychological and global recovery from 1 to 6 months after complicated mild traumatic brain injury (cmTBI).

participantsA total of 330 persons with cmTBI defined as Glasgow Coma Scale score of 13 to 15 in emergency department, with well-defined abnormalities on neuroimaging.

methodsEnrollment within 24 hours of injury with follow-up at 1, 3, and 6 months. MEASURES: Glasgow Outcome Scale-Extended, California Verbal Learning Test II, and Controlled Oral Word Association Test. Duration of PTA was retrospectively measured with structured interview at 30 days postinjury.

resultsDespite all having a Glasgow Coma Scale Score of 13 to 15, a quarter of the sample had a PTA duration of greater than 7 days; half had PTA duration of 1 of 7 days. Both cognitive performance and Extended Glasgow Outcome Scale outcomes were strongly associated with time since injury and PTA duration, with those with PTA duration of greater than 1 week showing residual moderate disability at 6-month assessment.

conclusionsFindings reinforce importance of careful measurement of duration of PTA to refine outcome prediction and allocation of resources to those with cmTBI. Future research would benefit from standardization in computed tomographic criteria and use of severity indices beyond Glasgow Coma Scale to characterize cmTBI.

Indexed as

AdolescentAdultAmnesiaBrain ConcussionCytidine Diphosphate CholineFemaleGlasgow Coma ScaleGlasgow Outcome ScaleHumansMaleMiddle AgedNeuroprotective AgentsNeuropsychological TestsYoung AdultCytidine Diphosphate CholineNeuroprotective Agents

Identifiers

PMID26828710
PMCPMC4738168
OpenAlexW2328293035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.