Evidence map›Paper›PMID 26828687›Full record

ArticleBiomaterials2016

Micellar and structural stability of nanoscale amphiphilic polymers: Implications for anti-atherosclerotic bioactivity.

Yingyue Zhang, Qi Li, William J Welsh, Prabhas V Moghe, Kathryn E Uhrich

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 87 citations in OpenAlex.

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  12. Nanomedicines for dysfunctional macrophage-associated diseases.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yingyue ZhangDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
Qi LiDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
William J WelshDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick 08901, USA.
Prabhas V MogheDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Kathryn E UhrichDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA; Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: keuhrich@rci.rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

Synthetic Counter-ligands for Inhibition of AtherosclerosisR01HL107913 · NHLBI · RUTGERS, THE STATE UNIV OF N.J. · PI MOGHE, PRABHAS V, UHRICH, KATHRYN ELIZABETH · 2011 to 2014
$2.3M
NHLBI NIH HHS R01 HL107913
6 · The paper itself

Abstract

Atherosclerosis, a leading cause of mortality in developed countries, is characterized by the buildup of oxidized low-density lipoprotein (oxLDL) within the vascular intima, unregulated oxLDL uptake by macrophages, and ensuing formation of arterial plaque. Amphiphilic polymers (AMPs) comprised of a branched hydrophobic domain and a hydrophilic poly(ethylene glycol) (PEG) tail have shown promising anti-atherogenic effects through direct inhibition of oxLDL uptake by macrophages. In this study, five AMPs with controlled variations were evaluated for their micellar and structural stability in the presence of serum and lipase, respectively, to develop underlying structure-atheroprotective activity relations. In parallel, molecular dynamics simulations were performed to explore the AMP conformational preferences within an aqueous environment. Notably, AMPs with ether linkages between the hydrophobic arms and sugar backbones demonstrated enhanced degradation stability and storage stability, and also elicited enhanced anti-atherogenic bioactivity. Additionally, AMPs with increased hydrophobicity elicited increased atheroprotective bioactivity in the presence of serum. These studies provide key insights for designing more serum-stable polymeric micelles as prospective cardiovascular nanotherapies.

Indexed as

MicellesAnionsAtherosclerosisFluorescence Resonance Energy TransferHumansLipoproteins, LDLMacrophagesMolecular Dynamics SimulationMonocytesNanoparticlesParticle SizePolymersSerumSurface-Active AgentsTemperatureAnionsLipoproteins, LDLMicellesoxidized low density lipoproteinPolymersSurface-Active AgentsAmphiphilic polymersAtherosclerosisMicelleSerum stabilityStructure–activity relationship

Identifiers

PMID26828687
PMCPMC4755878
OpenAlexW2222005610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.