ArticleJournal of personalized medicine2016
The Changing Landscape of Molecular Diagnostic Testing: Implications for Academic Medical Centers.
Article in Journal of personalized medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Comprehensive Custom NGS Panel Validation for the Improvement of the Stratification of B-Acute Lymphoblastic Leukemia Patients.Journal of personalized medicine · 2020Article
- Diagnostic and molecular testing patterns in patients with newly diagnosed acute myeloid leukemia in the ConnectEJHaem · 2020Article
- A Stakeholders Approach for Curriculum Development of Master's Degree in Molecular Diagnostics.Advances in medical education and practice · 2020Article
- Sources of discordance among germ-line variant classifications in ClinVar.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- An example of the utility of genomic analysis for fast and accurate clinical diagnosis of complex rare phenotypes.Orphanet journal of rare diseases · 2017Article
- Clinical Impact of Genomic Information in Pediatric Leukemia.Frontiers in pediatrics · 2017Article
- Implementing Personalized Medicine in the Academic Health Center.Journal of personalized medicine · 2016Article
- Infrastructure for Personalized Medicine at Partners HealthCare.Journal of personalized medicine · 2016Article
- Biological determinants of health: Genes, microbes, and metabolism exemplars of nursing science.Nursing outlookArticle
- The Genomics Organization for Academic Laboratories (GOAL): A vision for a genomics future for academic pathology.Academic pathologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Over the last decade, the field of molecular diagnostics has undergone tremendous transformation, catalyzed by the clinical implementation of next generation sequencing (NGS). As technical capabilities are enhanced and current limitations are addressed, NGS is increasingly capable of detecting most variant types and will therefore continue to consolidate and simplify diagnostic testing. It is likely that genome sequencing will eventually serve as a universal first line test for disorders with a suspected genetic origin. Academic Medical Centers (AMCs), which have been at the forefront of this paradigm shift are now presented with challenges to keep up with increasing technical, bioinformatic and interpretive complexity of NGS-based tests in a highly competitive market. Additional complexity may arise from altered regulatory oversight, also triggered by the unprecedented scope of NGS-based testing, which requires new approaches. However, these challenges are balanced by unique opportunities, particularly at the interface between clinical and research operations, where AMCs can capitalize on access to cutting edge research environments and establish collaborations to facilitate rapid diagnostic innovation. This article reviews present and future challenges and opportunities for AMC associated molecular diagnostic laboratories from the perspective of the Partners HealthCare Laboratory for Molecular Medicine (LMM).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.