ReviewInternational journal of molecular sciences2016
Usefulness of Intratracheal Instillation Studies for Estimating Nanoparticle-Induced Pulmonary Toxicity.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Environmental exposure to rare earth elements and respiratory health: an emerging public health concern.Frontiers in public health · 2026Review
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- Repeated intratracheal instillation effects of commonly used vehicles in toxicity studies with mice.Scientific reports · 2024Article
- Therapeutic Effects of (+)-Afzelechin on Particulate Matter-Induced Pulmonary Injury.Biomolecules & therapeutics · 2024Article
- Identifying the Relationship between PMToxics · 2023Article
- Therapeutic Effects of Cornuside on Particulate Matter-Induced Lung Injury.International journal of molecular sciences · 2023Article
- Indoor PMIndoor air · 2022Article
- Cirsilineol Treatment Attenuates PMInternational journal of molecular sciences · 2022Article
- Adverse effects of air pollution-derived fine particulate matter on cardiovascular homeostasis and disease.Trends in cardiovascular medicine · 2022Review
- Polymeric Nanoparticles for Inhaled Vaccines.Polymers · 2022Review
- Molecular Insight into the Therapeutic Effects of Stem Cell-Derived Exosomes in Respiratory Diseases and the Potential for Pulmonary Delivery.International journal of molecular sciences · 2022Review
- Article
- Comparison of acute inhalation toxicity of sulfuric acid by the inhalation and intratracheal instillation methods.Journal of toxicologic pathology · 2021Article
- Examination of Surfactant Protein D as a Biomarker for Evaluating Pulmonary Toxicity of Nanomaterials in Rat.International journal of molecular sciences · 2021Article
- Local Toxicity of Biocides after Direct and Aerosol Exposure on the Human Skin Epidermis and Airway Tissue Models.Toxics · 2021Article
- Time-course comparison of pulmonary inflammation induced by intratracheal instillation of four different nickel oxide nanoparticles in male Fischer rats.Journal of toxicologic pathology · 2021Article
- Assessment of Cytokine-Induced Neutrophil Chemoattractants as Biomarkers for Prediction of Pulmonary Toxicity of Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Article
- TiOInternational journal of nanomedicine · 2020Article
- Amelioration of PMRespiratory research · 2019Article
- Bactericidal and Cytotoxic Properties of Silver Nanoparticles.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhalation studies are the gold standard for the estimation of the harmful effects of respirable chemical substances, while there is limited evidence of the harmful effects of chemical substances by intratracheal instillation. We reviewed the effectiveness of intratracheal instillation studies for estimating the hazards of nanoparticles, mainly using papers in which both inhalation and intratracheal instillation studies were performed using the same nanoparticles. Compared to inhalation studies, there is a tendency in intratracheal instillation studies that pulmonary inflammation lasted longer in the lungs. A difference in pulmonary inflammation between high and low toxicity nanoparticles was observed in the intratracheal instillation studies, as in the inhalation studies. Among the endpoints of pulmonary toxicity, the kinetics of neutrophil counts, percentage of neutrophils, and chemokines for neutrophils and macrophages, heme oxygenase-1 (HO-1) in bronchoalveolar lavage fluid (BALF), reflected pulmonary inflammation, suggesting that these markers may be considered the predictive markers of pulmonary toxicity in both types of study. When comparing pulmonary inflammation between intratracheal instillation and inhalation studies under the same initial lung burden, there is a tendency that the inflammatory response following the intratracheal instillation of nanoparticles is greater than or equal to that following the inhalation of nanoparticles. If the difference in clearance in both studies is not large, the estimations of pulmonary toxicity are close. We suggest that intratracheal instillation studies can be useful for ranking the hazard of nanoparticles through pulmonary inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.