Evidence map›Paper›PMID 26828330›Full record

ReviewCurrent protocols in toxicology2016

Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment.

Jamie C DeWitt, Dori R Germolec, Robert W Luebke, Victor J Johnson

Abstract readReview
In one paragraph

Review in Current protocols in toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Public Health Risks of PFAS-Related Immunotoxicity Are Real.Current environmental health reports · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Severity of COVID-19 at elevated exposure to perfluorinated alkylates.medRxiv : the preprint server for health sciences · 2020
    Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jamie C DeWittDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Dori R GermolecDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina.
Robert W LuebkeCardiopulmonary and Immunotoxicology Branch, United States Environmental Protection Agency, Research Triangle Park, North Carolina.
Victor J JohnsonBurleson Research Technologies, Morrisville, North Carolina.
East Carolina University · USNational Institute of Environmental Health Sciences · USResearch Triangle Park Foundation · US

Funding

Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

This overview is an update of the unit originally published in 2004. While the basic tenets of immunotoxicity have not changed in the past 10 years, several publications have explored the application of immunotoxicological data to the risk assessment process. Therefore, the goal of this unit is still to highlight relationships between xenobiotic-induced immunosuppression and risk of clinical diseases progression. In immunotoxicology, this may require development of models to equate moderate changes in markers of immune functions to potential changes in incidence or severity of infectious diseases. For most xenobiotics, exposure levels and disease incidence data are rarely available, and safe exposure levels must be estimated based on observations from experimental models or human biomarker studies. Thus, it is important to establish a scientifically sound framework that allows accurate and quantitative interpretation of experimental or biomarker data in the risk assessment process.

Indexed as

Immune ToleranceAnimalsAutoimmune DiseasesBiomarkersCommunicable DiseasesDisease Models, AnimalHumansImmune SystemImmunosuppression TherapyImmunotoxinsNeoplasmsRisk AssessmentXenobioticsBiomarkersImmunotoxinsXenobioticsimmunosuppressionimmunotoxicityxenobiotic exposure

Identifiers

PMID26828330
PMCPMC4780336
OpenAlexW1962703395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.