Evidence map›Paper›PMID 26827931›Full record

SynthesisReproductive toxicology (Elmsford, N.Y.)2016

A genomics-based framework for identifying biomarkers of human neurodevelopmental toxicity.

J F Robinson, M J Gormley, S J Fisher

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Reproductive toxicology (Elmsford, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J F RobinsonCenter for Reproductive Sciences, University of California, San Francisco (UCSF), United States; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF), United States; The Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco (UCSF), United States. Electronic address: Joshua.Robinson@ucsf.edu.
M J GormleyCenter for Reproductive Sciences, University of California, San Francisco (UCSF), United States; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF), United States; The Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco (UCSF), United States.
S J FisherCenter for Reproductive Sciences, University of California, San Francisco (UCSF), United States; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF), United States; The Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco (UCSF), United States; Division of Maternal Fetal Medicine, University of California, San Francisco (UCSF), United States; Department of Anatomy, University of California, San Francisco (UCSF), United States; Human Embryonic Stem Cell Program, University of California, San Francisco (UCSF), United States.
University of California, San Francisco · US

Funding

Polybrominated Diphenyl Ether Effects on Human Neuronal DevelopmentR00ES023846 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROBINSON, JOSHUA FREDERICK · 2016 to 2018
$740k
Polybrominated Diphenyl Ether Effects on Human Neuronal DevelopmentK99ES023846 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROBINSON, JOSHUA FREDERICK · 2014 to 2015
$200k
NIEHS NIH HHS K99 ES023846NIEHS NIH HHS R00 ES023846
6 · The paper itself

Abstract

Human embryonic stem cell (hESC) neural differentiation models have tremendous potential for evaluating environmental compounds in terms of their ability to induce neurodevelopmental toxicity. Genomic based-approaches are being applied to identify changes underlying normal human development (in vitro and in vivo) and the effects of environmental exposures. Here, we investigated whether mechanisms that are shared between hESC neural differentiation model systems and human embryos are candidate biomarkers of developmental toxicities for neurogenesis. We conducted a meta-analysis of transcriptomic datasets with the goal of identifying differentially expressed genes that were common to the hESC-model and human embryos. The overlapping NeuroDevelopmental Biomarker (NDB) gene set contained 304 genes which were enriched for their roles in neurogenesis. These genes were investigated for their utility as candidate biomarkers in the context of toxicogenomic studies focused on the effects of retinoic acid, valproic acid, or carbamazepine in hESC models of neurodifferentiation. The results revealed genes, including 13 common targets of the 3 compounds, that were candidate biomarkers of neurotoxicity in hESC-based studies of environmental toxicants.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsBiomarkersCell DifferentiationEmbryonic Stem CellsGenomicsHumansNeurogenesisNeurotoxicity SyndromesRatsZebrafishBiomarkersEnvironmental exposuresGenomicsHuman developmentHuman embryonic stem cellsMeta-analysesNeurodevelopmentNeuronNeurotoxicity

Identifiers

PMID26827931
PMCPMC4867143
OpenAlexW2288875074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.