ReviewThe Alkaloids. Chemistry and biology2016
Sarpagine and Related Alkaloids.
Review in The Alkaloids. Chemistry and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Unified Chemical Synthesis of Corynanthe-Sarpagine-Ajmaline Type Monoterpene Indole Alkaloids: A Biomimetic Approach.JACS Au · 2025Article
- A review on the sulfur ylide-mediated Corey-Chaykovsky reaction: a powerful approach to natural product synthesis.RSC advances · 2025Review
- Azine Dearomatization in Natural Product Total Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Antibacterial and antioxidant potentials, detection of host origin compounds, and metabolic profiling of endophytic Bacillus spp. isolated from Rauvolfia serpentina (L.) Benth. ex Kurz.Scientific reports · 2025Article
- Function and Evolution of the Plant MES Family of Methylesterases.Plants (Basel, Switzerland) · 2024Review
- Review
- A Short Synthesis of Vellosimine and Its Derivatives.The Journal of organic chemistry · 2023Article
- Cellular Stress-Induced Metabolites inJournal of natural products · 2022Article
- Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB InhibitorMolecules (Basel, Switzerland) · 2022Article
- Asymmetric synthesis of N-bridged [3.3.1] ring systems by phosphonium salt/Lewis acid relay catalysis.Nature communications · 2022Article
- Bisindole Alkaloids from theMolecules (Basel, Switzerland) · 2021Review
- Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera.Molecules (Basel, Switzerland) · 2021Review
- Cytochrome P450 Enzymes as Key Drivers of Alkaloid Chemical Diversification in Plants.Frontiers in plant science · 2021Review
- Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review.Molecules (Basel, Switzerland) · 2016Review
- Total Synthesis of Macrocarpines D and E via an Enolate-Driven Copper-Mediated Cross-Coupling Process: Replacement of Catalytic Palladium with Copper Iodide.Organic letters · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The sarpagine-related macroline and ajmaline alkaloids share a common biosynthetic origin, and bear important structural similarities, as expected. These indole alkaloids are widely dispersed in 25 plant genera, principally in the family Apocynaceae. Very diverse and interesting biological properties have been reported for this group of natural products. Isolation of new sarpagine-related alkaloids and the asymmetric synthesis of these structurally complex molecules are of paramount importance to the synthetic and medicinal chemists. A total of 115 newly isolated sarpagine-related macroline and ajmaline alkaloids, along with their physicochemical properties have been included in this chapter. A general and efficient strategy for the synthesis of these monomeric alkaloids, as well as bisindoles, has been presented, which involves application of the asymmetric Pictet-Spengler reaction (>98% ee) as a key step because of the ease of scale up of the tetracyclic template. Also included in this chapter are the syntheses of the sarpagine-related alkaloids, published since 2000.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.