ArticleVeterinary immunology and immunopathology2016
Immunologic progression of canine leishmaniosis following vertical transmission in United States dogs.
Article in Veterinary immunology and immunopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Sire risk factors for vertical transmission of Leishmania infantum by the dam.PLoS neglected tropical diseases · 2026Article
- LeishTec vaccination disrupts vertical transmission of Leishmania infantum.PLoS neglected tropical diseases · 2025Article
- The immune response in canine and human leishmaniasis and how this influences the diagnosis- a review and assessment of recent research.Frontiers in cellular and infection microbiology · 2023Review
- Humoral and Cellular Immune Response in Asymptomatic Dogs with Visceral Leishmaniasis: A Review.Vaccines · 2022Review
- Visceral Leishmaniasis and the Skin: Dermal Parasite Transmission to Sand Flies.Pathogens (Basel, Switzerland) · 2022Review
- Possibility ofCurrent tropical medicine reports · 2022Review
- Canine leishmaniosis in Tunisia: Growing prevalence, larger zones of infection.PLoS neglected tropical diseases · 2021Article
- Early onset of clinical leishmaniosis in a litter of pups with evidence of in utero transmission.Parasites & vectors · 2021Article
- One Health Approach to Leishmaniases: Understanding the Disease Dynamics through Diagnostic Tools.Pathogens (Basel, Switzerland) · 2020Review
- Bayesian compartmental models and associated reproductive numbers for an infection with multiple transmission modes.Biometrics · 2020Article
- The balancing act: Immunology of leishmaniosis.Research in veterinary science · 2020Review
- Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners.Parasites & vectors · 2020Article
- Article
- The role of healthy dog carriers of Babesia microti-like piroplasms.Parasites & vectors · 2019Article
- Maternal Leishmania infantum infection status has significant impact on leishmaniasis in offspring.PLoS neglected tropical diseases · 2019Article
- Comorbid infections induce progression of visceral leishmaniasis.Parasites & vectors · 2019Article
- Safety Analysis ofThe American journal of tropical medicine and hygiene · 2018Article
- Leishmania-Derived Trimannose Modulates the Inflammatory Response To Significantly Reduce Leishmania major-Induced Lesions.Infection and immunity · 2018Article
- Article
- Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Canine leishmaniosis (CanL) is caused by Leishmania infantum, an obligate intracellular protozoan parasite, endemic in U.S. hunting dog populations. CanL has been found in dogs in 28 states and two Canadian provinces. Previous studies by our group, (Boggiatto et al., 2011), demonstrated that vertical transmission of Leishmania was the predominant means of transmission within U.S. dogs. Very little is known regarding how this alternative means of transmission, alters the long-term immunity and clinical presentation of leishmaniosis in dogs born to a positive bitch. This study follows the immunological progression of CanL in three pups after birth to an infected bitch. During the course of the study, these dogs were tested every six months over the course of six years. Both immunologic (IFN-γ, T cell proliferation, antibody production) and parasitological parameters (qPCR) of vertically-infected dogs were measured. Within the six years after birth to an L. infantum-infected, oligosymptomatic bitch, all dogs had at least one L. infantum PCR-positive test. Interestingly, despite living in the same location for their entire lives and being full siblings, these pups demonstrate three different disease progression patterns of L. infantum infection. One dog progressed to oligosymptomatic disease, maintaining a positive titer and had intermittent positive PCR results. One asymptomatic dog had positive serological titers and demonstrated a robust CD4(+) immune response to infection. The third dog had a negligible response to L. infantum antigen and was healthy. This work demonstrates the biologic variability associated with vertically-transmitted infection similar to the variety of presentations observed during vector-borne leishmaniosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.