ArticleNeurobiology of aging2016
I forgot when I lost my grip-strong associations between cognition and grip strength in level of performance and change across time in relation to impending death.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Associations Between Aging-Related Changes in Grip Strength and Cognitive Function in Older Adults: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Pooled it
- Observational Evidence of the Association Between Handgrip Strength, Hand Dexterity, and Cognitive Performance in Community-Dwelling Older Adults: A Systematic Review.Journal of epidemiology · 2018Pooled it
- Predicting the onset of dementia with longitudinal performance-based measures of physical function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Patient-Reported Outcomes Can Serve as a Functional Substitute for Grip Strength.Journal of wrist surgery · 2024Article
- Higher handgrip strength is linked to higher salience ventral attention functional network segregation in older adults.Communications biology · 2024Article
- Longitudinal Relationship Between Handgrip Strength and Cognitive Function in a European Multicentric Population Older Than 50 Years.Physical therapy · 2023Article
- Detrimental effects of effortful physical exertion on a working memory dual-task in older adults.Psychology and aging · 2023Article
- Balance performance and grip strength as predictors of cognitive function among community-dwelling older adults in the USA.Journal of frailty, sarcopenia and falls · 2023Article
- Prevalence of dynapenia and overlap with disability, depression, and executive dysfunction.Revista de saude publica · 2023Article
- Grip Strength Trajectories and Cognition in English and Chilean Older Adults: A Cross-Cohort Study.Journal of personalized medicine · 2022Article
- Social, behavioural, and functional characteristics of community-dwelling South Korean adults with moderate and severe cognitive impairment.International journal of methods in psychiatric research · 2022Article
- Asymmetrical Handgrip Strength Is Associated with Lower Cognitive Performance in the Elderly.Journal of clinical medicine · 2022Article
- Combined effects of handgrip strength and sensory impairment on the prevalence of cognitive impairment among older adults in Korea.Scientific reports · 2022Article
- A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls.Healthcare (Basel, Switzerland) · 2022Article
- Association between Handgrip Strength and Cognitive Function in Older Adults: Korean Longitudinal Study of Aging (2006-2018).International journal of environmental research and public health · 2022Article
- The Relationship Between Muscle Strength and Cognitive Performance Across Alzheimer's Disease Clinical Continuum.Frontiers in neurology · 2022Article
- Association between handgrip strength and cognition in a Chinese population with Alzheimer's disease and mild cognitive impairment.BMC geriatrics · 2021Article
- Higher Handgrip Strength Is Linked to Better Cognitive Performance in Chinese Adults with Hypertension.Brain sciences · 2021Article
- Challenging the relationship of grip strength with cognitive status in older adults.International journal of geriatric psychiatry · 2021Article
- What Matters and What Matters Most for Survival After age 80? A Multidisciplinary Exploration Based on Twin Data.Frontiers in psychology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
An association between level of cognitive function and grip strength is well established, whereas evidence for longitudinal associations of change in the 2 functions is still unclear. We examined associations between cognition and grip strength in levels of performance and in longitudinal change in late life in a population-based sample, aged ≥80 years at baseline, followed until death. The sample consisted of 449 nondemented individuals drawn from the OCTO-Twin Study. A test battery assessing 6 cognitive domains and grip strength was administered at 5 occasions with measurements intervals of 2 years. We fitted time to death bivariate growth curve models, adjusted for age, education, and sex which resulted in associations between grip strength and cognition in both levels of performance (across all cognitive domains) and rates of change (in 4 of 6 domains). These results show that cognition and grip strength change conjointly in later life and that the association between cognition and grip strength is stronger before death than earlier in life.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.