Evidence map›Paper›PMID 26827638›Full record

ArticleNeurobiology of aging2016

Aβ 1-40 enhances the proliferation of human diploid fibroblasts.

Lindsey Theda, Michelle K Drews, Galynn Zitnik, Junko Oshima, George M Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lindsey ThedaDepartment of Pathology, University of Washington, Seattle, WA, USA.
Michelle K DrewsDepartment of Pathology, University of Washington, Seattle, WA, USA.
Galynn ZitnikDepartment of Pathology, University of Washington, Seattle, WA, USA.
Junko OshimaDepartment of Pathology, University of Washington, Seattle, WA, USA; Department of Medicine, Chiba University, Chiba, Japan.
George M MartinDepartment of Pathology, University of Washington, Seattle, WA, USA. Electronic address: gmmartin@u.washington.edu.

Funding

International Registry of Werner SyndromeR24AG042328 · NIA · UNIVERSITY OF WASHINGTON · PI MARTIN, GEORGE M., OSHIMA, JUNKO · 2012 to 2015
$743k
NIA NIH HHS R24 AG042328NIA NIH HHS R24AG42328
6 · The paper itself

Abstract

There is a vast literature on the role of beta amyloid (Aβ) peptides in the pathogenesis of Alzheimer's disease. However, there is a paucity of research on the potential physiological functions of these evolutionarily conserved products of the Aβ precursor protein. Based on previous studies in neuroblastoma cells, we hypothesized that Aβ may contribute to the proliferation of somatic cells. We present evidence supporting this hypothesis for the case of cultured human skin fibroblasts immortalized with the catalytic subunit of human telomerase (hTERT). Optimal concentrations ranged from 100 pM-10 nM, depending on the nature of the assay.

Indexed as

Amyloid beta-PeptidesCell LineCell ProliferationFibroblastsHumansPeptide FragmentsSkinTelomeraseAmyloid beta-Peptidesamyloid beta-protein (1-40)Peptide FragmentsTelomeraseAlzheimer's diseaseBeta amyloidCell culture

Identifiers

PMID26827638
PMCPMC4735734

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.