ArticleBrain research2016
Single body parts are processed by individual neurons in the mouse dorsolateral striatum.
Article in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Localization and connections of the tail of caudate and caudal putamen in mouse brain.Frontiers in neural circuits · 2025Article
- The Interactions of Temporal and Sensory Representations in the Basal Ganglia.Advances in experimental medicine and biology · 2024Review
- Pathological cell assembly dynamics in a striatal MSN network model.Frontiers in computational neuroscience · 2024Article
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- Nucleus accumbens shell neurons' early sensitivity to cocaine is associated with future increases in drug intake.Addiction neuroscience · 2023Article
- Lack of action monitoring as a prerequisite for habitual and chunked behavior: Behavioral and neural correlates.iScience · 2023Article
- Striatal direct pathway neurons play leading roles in accelerating rotarod motor skill learning.iScience · 2022Article
- Continuous Representations of Speed by Striatal Medium Spiny Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Sensory representations in the striatum provide a temporal reference for learning and executing motor habits.Nature communications · 2019Article
- No Discrete Start/Stop Signals in the Dorsal Striatum of Mice Performing a Learned Action.Current biology : CB · 2018Article
- Cyclic AMP-producing chemogenetic activation of indirect pathway striatal projection neurons and the downstream effects on the globus pallidus and subthalamic nucleus in freely moving mice.Journal of neurochemistry · 2018Article
- Homogeneous processing in the striatal direct and indirect pathways: single body part sensitive type IIb neurons may express either dopamine receptor D1 or D2.The European journal of neuroscience · 2017Article
- Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum.Journal of neurophysiology · 2017Article
- Representation of the body in the lateral striatum of the freely moving rat: Fast Spiking Interneurons respond to stimulation of individual body parts.Brain research · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Interest in the dorsolateral striatum (DLS) has generated numerous scientific studies of its neuropathologies, as well as its roles in normal sensorimotor integration and learning. Studies are informed by knowledge of DLS functional organization, the guiding principle being its somatotopic afferent projections from primary somatosensory (S1) and motor (M1) cortices. The potential to connect behaviorally relevant function to detailed structure is elevated by mouse models, which have access to extensive genetic neuroscience tool kits. Remaining to be demonstrated, however, is whether the correspondence between S1/M1 corticostriatal terminal distributions and the physiological properties of DLS neurons demonstrated in rats and non-human primates exists in mice. Given that the terminal distribution of S1/M1 projections to the DLS in mice is similar to that in rats, we studied whether firing rates (FRs) of DLS neurons in awake, behaving mice are related to activity of individual body parts. MSNs exhibited robust, selective increases in FR during movement or somatosensory stimulation of single body parts. Properties of MSNs, including baseline FRs, locations, responsiveness to stimulation, and proportions of responsive neurons were similar to properties observed in rats. Future studies can be informed by the present demonstration that the mouse lateral striatum functions as a somatic sensorimotor sector of the striatum and appears to be a homolog of the primate putamen, as demonstrated in rats (Carelli and West, 1991).
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