SynthesisMedicina oral, patologia oral y cirugia bucal2016
Recurrent aphthous stomatitis and Helicobacter pylori.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Systematic review and meta-analysis of oxidative stress and antioxidant markers in recurrent aphthous stomatitis.BMC oral health · 2023Pooled it
- Effect of Lozenges Containing Lactobacillus reuteri on the Severity of Recurrent Aphthous Ulcers: a Pilot Study.Probiotics and antimicrobial proteins · 2020Trial
- Finasteride-induced recurrent aphthous ulceration-like lesions: a case report with dechallenge-rechallenge confirmation.BMC oral health · 2026Article
- Polymicrobial interactions ofJournal of oral microbiology · 2025Review
- Classification-Predictive Model Based on Artificial Neural Network Validated by Histopathology and Direct Immunofluorescence for the Diagnosis of Oral Lichen Planus.Diagnostics (Basel, Switzerland) · 2024Article
- Comparison of the main pathogenic microorganisms of various common oral diseases in children and adults.Pediatric discovery · 2023Article
- Detection and Analysis of the Oral Flora in Patients with Recurrent Aphthous Stomatitis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Oral ulcers in children- a clinical narrative overview.Italian journal of pediatrics · 2021Review
- Recurrent Aphthous Stomatitis Improved after Eradication Therapy forCase reports in gastrointestinal medicine · 2021Article
- Assessment of Efficacy of 5% Topical Amlexanox and 0.1% Topical Triamcinolone Acetonide in Management of Recurrent Aphthous Stomatitis.Journal of pharmacy & bioallied sciences · 2020Article
- Gene mapping and functional annotation of GWAS of oral ulcers using FUMA software.Scientific reports · 2020Article
- LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence.BMC oral health · 2020Article
- Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.Nature communications · 2019Article
- Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review.Head and neck pathology · 2019Review
- Recurrent Aphthous Stomatitis: A Review.The Journal of clinical and aesthetic dermatology · 2017Review
- Association of bedtime with recurrent aphthous stomatitis: A cross-sectional study among health-care professional students.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrent aphthous stomatitis (RAS) is a recurrent painful ulcerative disorder that commonly affects the oral mucosa. Local and systemic factors such as trauma, food sensitivity, nutritional deficiencies, systemic conditions, immunological disorders and genetic polymorphisms are associated with the development of the disease. Helicobacter pylori (H. pylori) is a gram-negative, microaerophile bacteria, that colonizes the gastric mucosa and it was previously suggested to be involved in RAS development. In the present paper we reviewed all previous studies that investigated the association between RAS and H. pylori. MATERIAL AND
methodsA search in Pubmed (MEDLINE) databases was made of articles published up until July 2015 using the following keywords: Helicobacter Pylori or H. pylori and RAS or Recurrent aphthous stomatitis.
resultsFifteen experimental studies that addressed the relationship between infection with H. pylori and the presence of RAS and three reviews, including a systematic review and a meta-analysis were included in this review. The studies reviewed used different methods to assess this relationship, including PCR, nested PCR, culture, ELISA and urea breath test. A large variation in the number of patients included in each study, as well as inclusion criteria and laboratorial methods was observed. H. pylori can be detected in the oral mucosa or ulcerated lesion of some patients with RAS. The quality of the all studies included in this review was assessed using levels of evidence based on the University of Oxford's Center for Evidence Based Medicine Criteria.
conclusionsAlthough the eradication of the infection may affect the clinical course of the oral lesions by undetermined mechanisms, RAS ulcers are not associated with the presence of the bacteria in the oral cavity and there is no evidence that H. pylori infection drives RAS development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.