ArticleProceedings of the National Academy of Sciences of the United States of America1989
Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
84 citing papers in PubMed, 242 citations in OpenAlex.
- Dysregulation of anti-Ro60 B cell autoreactivity in systemic lupus erythematosus.bioRxiv : the preprint server for biology · 2026Article
- B Cell Subsets and Atherosclerosis: Updates and Emerging Concepts.Immunological reviews · 2026Review
- ImmunoMatch learns and predicts cognate pairing of heavy and light immunoglobulin chains.Nature methods · 2026Article
- B Cells With Complementary B Cell Receptors Can Kill Each Other.European journal of immunology · 2025Article
- Immunological mechanisms of tolerance: Central, peripheral and the role of T and B cells.Asia Pacific allergy · 2023Review
- Development of a Cytotoxic Antibody-Drug Conjugate Targeting Membrane Immunoglobulin E-Positive Cells.International journal of molecular sciences · 2023Article
- TLR7 and IgM: Dangerous Partners in Autoimmunity.Antibodies (Basel, Switzerland) · 2023Review
- LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Autoreactive antibodies control blood glucose by regulating insulin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Rheumatoid factor IgM autoantibodies control IgG homeostasis.Frontiers in immunology · 2022Article
- Memory IgM protects endogenous insulin from autoimmune destruction.The EMBO journal · 2021Article
- B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells.Cells · 2021Review
- Primary Immune Responses and Affinity Maturation Are Controlled by IgD.Frontiers in immunology · 2021Article
- Safety Profile of a Virus-Like Particle-Based Vaccine Targeting Self-Protein Interleukin-5 in Horses.Vaccines · 2020Article
- Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Minding the gap: The impact of B-cell tolerance on the microbial antibody repertoire.Immunological reviews · 2019Review
- The five dimensions of B cell tolerance.Immunological reviews · 2019Review
- Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design.Retrovirology · 2018Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the fate of developing B cells in the presence and absence of the autoantigens to which they react, chimeric mice were constructed by injecting bone marrow cells from mice transgenic for rearranged immunoglobulin genes encoding an anti-H-2Kk antibody into irradiated recipients that did or did not express the H-2Kk antigen. In the presence of H-2Kk, the anti-H-2Kk-specific B cells were deleted from the spleen and lymph nodes, whereas in its absence, anti-H-2Kk cells were abundant. B cells bearing a low level of membrane immunoglobulin with the anti-H-2Kk idiotype were found in the bone marrows of H-2Kk recipients, suggesting that clonal deletion of autoreactive cells was occurring in the pre-B-cell to B-cell transitional stage of B-cell development.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.