Evidence map›Paper›PMID 26826305›Full record

ReviewJournal of controlled release : official journal of the Controlled Release Society2016

Biocomputing nanoplatforms as therapeutics and diagnostics.

A C Evans, N N Thadani, J Suh

Abstract readReview
In one paragraph

Review in Journal of controlled release : official journal of the Controlled Release Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. SemiSynBio: A new era for neuromorphic computing.Synthetic and systems biotechnology · 2024
    Review
  3. Catalyst-based biomolecular logic gates.Catalysts (Basel, Switzerland) · 2022
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Stimulus-responsive viral vectors for controlled delivery of therapeutics.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A C EvansDepartment of Bioengineering, Rice University, Houston, TX, United States.
N N ThadaniDepartment of Bioengineering, Rice University, Houston, TX, United States.
J SuhDepartment of Bioengineering, Rice University, Houston, TX, United States; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX, United States. Electronic address: jsuh@rice.edu.

Funding

MMP-targeted viral gene delivery vectors for treatment of infarcted heartR21HL126053 · NHLBI · RICE UNIVERSITY · PI SUH, JUNGHAE · 2015 to 2016
$428k
Matrilysin-Sensing Gene Delivery Vectors for Colorectal Cancer TherapyR21CA187316 · NCI · RICE UNIVERSITY · PI SUH, JUNGHAE · 2014 to 2015
$381k
NCI NIH HHS R21 CA187316NHLBI NIH HHS R21 HL126053
6 · The paper itself

Abstract

Biocomputing nanoplatforms are designed to detect and integrate single or multiple inputs under defined algorithms, such as Boolean logic gates, and generate functionally useful outputs, such as delivery of therapeutics or release of optically detectable signals. Using sensing modules composed of small molecules, polymers, nucleic acids, or proteins/peptides, nanoplatforms have been programmed to detect and process extrinsic stimuli, such as magnetic fields or light, or intrinsic stimuli, such as nucleic acids, enzymes, or pH. Stimulus detection can be transduced by the nanomaterial via three different mechanisms: system assembly, system disassembly, or system transformation. The increasingly sophisticated suite of biocomputing nanoplatforms may be invaluable for a multitude of applications, including medical diagnostics, biomedical imaging, environmental monitoring, and delivery of therapeutics to target cell populations.

Indexed as

Computers, MolecularAnimalsColorimetryDiagnostic ImagingDrug Delivery SystemsHumansMolecular ImagingNanoparticlesNanotechnologyBoolean logicDrug deliveryGene therapyImaging agentsLogic gatesNanoparticleReviewStimulus responsiveTargeted delivery

Identifiers

PMID26826305
PMCPMC4965337

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.