ArticleJournal of immunology (Baltimore, Md. : 1950)2016
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Coexistence of Psoriasis and Pemphigus: A Case Report of Pemphigus Vulgaris With a Review of the Literature.Clinical case reports · 2025Article
- A Global View of Pemphigus: Geographical Variations.Clinical reviews in allergy & immunology · 2024Review
- From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus.Frontiers in immunology · 2022Review
- Some Good and Some Bad: Sand Fly Salivary Proteins in the Control of Leishmaniasis and in Autoimmunity.Frontiers in cellular and infection microbiology · 2022Review
- Identification of a primary antigenic target of epitope spreading in endemic pemphigus foliaceus.Journal of autoimmunity · 2021Article
- Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus.JCI insight · 2020Article
- Pemphigus Vulgaris and Bullous Pemphigoid: Update on Diagnosis and Treatment.Dermatology practical & conceptual · 2020Review
- Walnut antigens can trigger autoantibody development in patients with pemphigus vulgaris through a "hit-and-run" mechanism.The Journal of allergy and clinical immunology · 2019Article
- IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study.Arthritis research & therapy · 2019Article
- Autoreactive IgG and IgA B Cells Evolve through Distinct Subclass Switch Pathways in the Autoimmune Disease Pemphigus Vulgaris.Cell reports · 2018Article
- Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope.Journal of autoimmunity · 2018Article
- A New Classification System for IgG4 Autoantibodies.Frontiers in immunology · 2018Review
- Humoral Epitope Spreading in Autoimmune Bullous Diseases.Frontiers in immunology · 2018Review
- Divergent Specificity Development of IgG1 and IgG4 Autoantibodies in Endemic Pemphigus Foliaceus (Fogo Selvagem).ImmunoHorizons · 2017Article
- Pemphigus.Nature reviews. Disease primers · 2017Review
- Non-infectious environmental antigens as a trigger for the initiation of an autoimmune skin disease.Autoimmunity reviews · 2016Review
- Immunohistochemistry for Immunoglobulin G4 in the Diagnosis of Pemphigus.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The etiology of human autoimmune diseases in general remains largely unknown, although the genetic and environmental interplay may be relevant. This applies to the autoimmune diseases of the skin such as the pemphigus phenotypes and others. In this group, there is an endemic form of pemphigus foliaceus (also known as fogo selvagem [FS]) in which the pathogenic IgG4 autoantibody response to the self-antigen desmoglein 1 (Dsg1) cross-reacts with the LJM11 sand fly salivary gland Ag. In this investigation, we dissected the IgG4 autoantibody repertoires used by FS patients in response to endogenous self-Dsg1 and exogenous LJM11 sand fly Ag. Based on analyses of the genetic clonal signatures of these Abs, our results indicate that there is a significant overlap between these two responses, as all identified IgG4 mAbs cross-react to both Dsg1 and LJM11 Ags. Germline H- and L-chain V gene Abs generated according to mutated cross-reactive mAbs preserved their reactivity to both Ags. Our findings suggest that both Dsg1 autoantigen and LJM11 environmental Ag could be the initial antigenic stimulants for the IgG4 autoimmune responses in FS. These results support our hypothesis that LJM11 Ag plays a substantial role in triggering the IgG4 autoantibody development in FS and provide new insights on how noninfectious environmental Ag(s) may drive the generation of autoantibodies in IgG4-related autoimmune diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.