ArticleBMJ open2016
Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05215080 (The Tolerance of Organic Formula Milk and Its Fecal Microbiome Characteristic in Infants), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Tolerance of Organic Formula Milk and Its Fecal Microbiome Characteristic in Infants
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between Smoking and Hypertension in Pregnancy Among Japanese Women: A Meta-analysis of Birth Cohort Studies in the Japan Birth Cohort Consortium (JBiCC) and JECS.Journal of epidemiology · 2023Pooled it
- Association Between Folic Acid Use and Serum One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women.Metabolites · 2026Article
- Environmental food allergen levels in the homes of 3-4-month-old infants: findings from the second phase Chiba study of mother and child health (2nd C-MACH).Scientific reports · 2026Article
- Cohort profile: Sub-cohort study on the second phase of the Chiba Study of Mother and Child Health (C-MACH), Japan.BMJ open · 2026Article
- Manual and automated assessments of general movements in neonates are associated with early autism risk at 18 months.Scientific reports · 2026Article
- Longitudinal changes of human milk oligosaccharides in Japan and their associations with maternal or infant characteristics.Frontiers in nutrition · 2026Article
- Article
- Risk of autism spectrum disorder at 18 months of age is associated with prenatal level of polychlorinated biphenyls exposure in a Japanese birth cohort.Scientific reports · 2024Article
- Second phase Chiba study of mother and child health (C-MACH): Japanese birth cohort study with multiomics analyses.BMJ open · 2024Article
- Changes in the intestinal microbiota of Japanese children during the first 3.5 years of life.Scientific reports · 2024Article
- Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women.Nutrients · 2024Article
- Spatiotemporal patterns of spontaneous movement in neonates are significantly linked to risk of autism spectrum disorders at 18 months old.Scientific reports · 2023Article
- Association ofNutrients · 2023Article
- Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Association between Total and Individual PCB Congener Levels in Maternal Serum and Birth Weight of Newborns: Results from the Chiba Study of Mother and Child Health Using Weighted Quantile Sum Regression.International journal of environmental research and public health · 2022Article
- Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review.Environmental health and preventive medicine · 2022Review
- Article
- Article
- Association between gut microbiota composition and glycoalbumin level during pregnancy in Japanese women: Pilot study from Chiba Study of Mother and Child Health.Journal of diabetes investigation · 2020Article
- Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort.The World Allergy Organization journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of non-communicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors--particularly the fetal environment and postbirth living environment--on children's health, and to identify potential biomarkers for these effects.
participantsThe C-MACH consists of three hospital-based cohorts. The study participants are pregnant women at <13 weeks gestation. Women who underwent an examination in one of the three hospitals received an explanation of the study. The participants consented to completing questionnaire surveys and the collection and storage of biological and house/environmental samples. Participants were provided unique study numbers. All of the data and biological specimens will be stored in the Chiba University Center for Preventive Medical Sciences and Chiba University Center for Preventive Medical Sciences BioBank, respectively. FINDINGS TO DATE: Consent to participate was obtained from 433 women. Of these women, 376 women completed questionnaires in the early gestational period. The mean age was 32.5 (4.4) years. The mean body mass index (BMI) was 21.1 (3.0) kg/m(2). Before pregnancy, 72.3% of the women had a BMI of 18.5-24.9 kg/m(2). During early pregnancy, 5.0% of the participants smoked. FUTURE PLANS: Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.
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