Evidence map›Paper›PMID 26826020›Full record

ArticleAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine2016

Building a Natural Language Processing Tool to Identify Patients With High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes.

Son Doan, Cleo K Maehara, Juan D Chaparro, Sisi Lu, Ruiling Liu, Amanda Graham, Erika Berry, Chun-Nan Hsu, John T Kanegaye, David D Lloyd and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  12. Privacy-preserving model learning on a blockchain network-of-networks.Journal of the American Medical Informatics Association : JAMIA · 2020
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  15. Identification of Inpatient Allergic Drug Reactions Using ICD-9-CM Codes.The journal of allergy and clinical immunology. In practice · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Son DoanDepartment of Biomedical Informatics, University of California, San Diego, CA.
Cleo K MaeharaDepartment of Biomedical Informatics, University of California, San Diego, CA.
Juan D ChaparroDepartment of Biomedical Informatics, University of California, San Diego, CA.
Sisi LuDepartment of Computer Science, University of Pittsburgh, Pittsburgh, PA.
Ruiling LiuThe University of Texas Health Science Center at Houston, Houston, TX.
Amanda GrahamChildren's Healthcare of Atlanta, Atlanta, GA.
Erika BerryDepartment of Pediatrics, University of California at San Diego, La Jolla, CA.
Chun-Nan HsuDepartment of Biomedical Informatics, University of California, San Diego, CA.
John T KanegayeDepartment of Pediatrics, University of California at San Diego, La Jolla, CA.
David D LloydChildren's Healthcare of Atlanta, Atlanta, GA.
Lucila Ohno-MachadoDepartment of Biomedical Informatics, University of California, San Diego, CA.
Jane C BurnsDepartment of Pediatrics, University of California at San Diego, La Jolla, CA.
Adriana H TremouletDepartment of Pediatrics, University of California at San Diego, La Jolla, CA.
Pediatric Emergency Medicine Kawasaki Disease Research Group
University of California, San Diego · USChildren's Healthcare of Atlanta · USEmory University · USRady Children's Hospital-San Diego · USThe University of Texas Health Science Center at Houston · USUniversity of Pittsburgh · US

Funding

iDASH: Integrating Data for Analysis, Anonymization, and SharingU54HL108460 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OHNO-MACHADO, LUCILA · 2010 to 2015
$19.1M
San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
NHLBI NIH HHS U54 HL108460NLM NIH HHS T15 LM011271
6 · The paper itself

Abstract

objectiveDelayed diagnosis of Kawasaki disease (KD) may lead to serious cardiac complications. We sought to create and test the performance of a natural language processing (NLP) tool, the KD-NLP, in the identification of emergency department (ED) patients for whom the diagnosis of KD should be considered.

methodsWe developed an NLP tool that recognizes the KD diagnostic criteria based on standard clinical terms and medical word usage using 22 pediatric ED notes augmented by Unified Medical Language System vocabulary. With high suspicion for KD defined as fever and three or more KD clinical signs, KD-NLP was applied to 253 ED notes from children ultimately diagnosed with either KD or another febrile illness. We evaluated KD-NLP performance against ED notes manually reviewed by clinicians and compared the results to a simple keyword search.

resultsKD-NLP identified high-suspicion patients with a sensitivity of 93.6% and specificity of 77.5% compared to notes manually reviewed by clinicians. The tool outperformed a simple keyword search (sensitivity = 41.0%; specificity = 76.3%).

conclusionsKD-NLP showed comparable performance to clinician manual chart review for identification of pediatric ED patients with a high suspicion for KD. This tool could be incorporated into the ED electronic health record system to alert providers to consider the diagnosis of KD. KD-NLP could serve as a model for decision support for other conditions in the ED.

Indexed as

Emergency Service, HospitalNatural Language ProcessingChildData MiningElectronic Health RecordsHumansMucocutaneous Lymph Node SyndromeSensitivity and Specificity

Identifiers

PMID26826020
PMCPMC5031359
OpenAlexW2344467404

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.