ArticleAmerican journal of epidemiology2016
Physical Trauma and Amyotrophic Lateral Sclerosis: A Population-Based Study Using Danish National Registries.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Risk factors associated with amyotrophic lateral sclerosis based on the observational study: a systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Meta-analytic evaluation of the association between head injury and risk of amyotrophic lateral sclerosis.European journal of epidemiology · 2017Pooled it
- Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry.Brain sciences · 2025Article
- Neurodegenerative disease risk among former international rugby union players.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study.Acta neurologica Scandinavica · 2022Article
- Demographics, clinical characteristics, and prognostic factors of amyotrophic lateral sclerosis in Midwest.Muscle & nerve · 2022Article
- Diagnostics of Amyotrophic Lateral Sclerosis: Up to Date.Diagnostics (Basel, Switzerland) · 2021Review
- Joint and interactive effects between health comorbidities and environmental exposures in predicting amyotrophic lateral sclerosis.International journal of hygiene and environmental health · 2021Article
- Risk factors for amyotrophic lateral sclerosis: A regional United States case-control study.Muscle & nerve · 2021Article
- Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment.Journal of neuroinflammation · 2020Review
- Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2020Review
- Therapeutic Approaches Targeting Protein Aggregation in Amyotrophic Lateral Sclerosis.Frontiers in molecular neuroscience · 2020Review
- Persistent Neurovascular Unit Dysfunction: Pathophysiological Substrate and Trigger for Late-Onset Neurodegeneration After Traumatic Brain Injury.Frontiers in neuroscience · 2020Article
- Poor Bone Quality in Patients With Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2020Article
- Thrombin and theFrontiers in neurology · 2019Review
- Study of occupation and amyotrophic lateral sclerosis in a Danish cohort.Occupational and environmental medicine · 2018Article
- Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood.Journal of neurology · 2018Article
- Effects of Ovariectomy in an hSOD1-G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS).Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Association of fractures with the incidence of amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2017Article
- Journal Club: Depression before and after diagnosis with amyotrophic lateral sclerosis.Neurology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Prior studies have suggested that physical trauma might be associated with the development of amyotrophic lateral sclerosis (ALS). We conducted a population-based, individually matched case-control study in Denmark to assess whether hospitalization for trauma is associated with a higher risk of developing ALS. There were 3,650 incident cases of ALS in the Danish National Patient Register from 1982 to 2009. We used risk-set sampling to match each case to 100 age- and sex-matched population controls alive on the date of the case's diagnosis. Odds ratios and 95% confidence intervals were calculated using a conditional logistic regression model. History of trauma diagnosis was also obtained from the Danish Patient Register. When traumas in the 5 years prior to the index date were excluded, there was a borderline association between any trauma and ALS (odds ratio (OR) = 1.09, 95% confidence interval (CI): 0.99, 1.19). A first trauma before age 55 years was associated with ALS (OR = 1.22, 95% CI: 1.08, 1.37), whereas first traumas at older ages were not (OR = 0.97, 95% CI: 0.85, 1.10). Our data suggest that physical trauma at earlier ages is associated with ALS risk. Age at first trauma could help explain discrepancies in results of past studies of trauma and ALS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.