Evidence map›Paper›PMID 26825925›Full record

Observational studyAmerican journal of epidemiology2016

Pregnancy as a Window to Future Cardiovascular Health: Design and Implementation of the nuMoM2b Heart Health Study.

David M Haas, Deborah B Ehrenthal, Matthew A Koch, Janet M Catov, Shannon E Barnes, Francesca Facco, Corette B Parker, Brian M Mercer, C Noel Bairey-Merz, Robert M Silver and 13 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02231398 (Pregnancy as a Window to Future Cardiovascular Health), which is not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02231398 completednot on this map

Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes as Predictors of Increased Risk Factors for Cardiovascular Disease

TypeobservationalSponsorRTI InternationalRan2014 to 2020Enrolled4,509ConditionsPregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode, Breathing-Related Sleep Disorder
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  8. Subtypes of Hypertension 2 to 7 Years After First Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2026
    Observational
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 15 institutions in 1 country.

David M Haas
Deborah B Ehrenthal
Matthew A Koch
Janet M Catov
Shannon E Barnes
Francesca Facco
Corette B Parker
Brian M Mercer
C Noel Bairey-Merz
Robert M Silver
Ronald J Wapner
Hyagriv N Simhan
Matthew K Hoffman
William A Grobman
Philip Greenland
Deborah A Wing
George R Saade
Samuel Parry
Phyllis C Zee
Uma M Reddy
Victoria L Pemberton
Dale R Burwen
National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network
Northwestern University · USUniversity of Pittsburgh · USNational Heart Lung and Blood Institute · USRTI International · USCase Western Reserve University · USCedars-Sinai Medical Center · USChristiana Care Health System · USColumbia University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USIndiana University – Purdue University Indianapolis · USIntermountain Healthcare · USThe University of Texas Medical Branch at Galveston · USUniversity of California, Irvine · USUniversity of Pennsylvania · USUniversity of Wisconsin–Madison · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063036 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2010 to 2015
$19.5M
Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes Supplement RequestU10HL119991 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2013 to 2018
$12.6M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Scientific and Technical CoreP2CHD047873 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine J. Curtis · 2014 to 2026
$5.1M
Pharmacokinetics and modeling of betamethasone therapy in threatened preterm birthR01HD088014 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2016 to 2020
$2.6M
Pregnancy as a Window for Future Cardiovascular HealthU10HL119992 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM · 2013 to 2016
$536k
Pregnancy as a Window to Future Cardiovascular HealthU10HL120034 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2013 to 2016
$483k
Pregnancy as a Window to Future Cardiovascular HealthU10HL120018 · NHLBI · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2013 to 2016
$395k
Pregnancy as a Window to Future Cardiovascular HealthU10HL120006 · NHLBI · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SIMHAN, HYAGRIV N · 2013 to 2016
$218k
NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1TR000153NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1TR001108NCATS NIH HHS UL1 TR001414NHLBI NIH HHS U10 HL119989NHLBI NIH HHS U10-HL119989NHLBI NIH HHS U10 HL119990NHLBI NIH HHS U10-HL119990NHLBI NIH HHS U10 HL119991NHLBI NIH HHS U10-HL119991NHLBI NIH HHS U10 HL119992NHLBI NIH HHS U10-HL119992NHLBI NIH HHS U10 HL119993NHLBI NIH HHS U10-HL119993NHLBI NIH HHS U10 HL120006NHLBI NIH HHS U10-HL120006NHLBI NIH HHS U10 HL120018NHLBI NIH HHS U10-HL120018NHLBI NIH HHS U10 HL120019NHLBI NIH HHS U10-HL120019NHLBI NIH HHS U10 HL120034NHLBI NIH HHS U10-HL120034NICHD NIH HHS P2C HD047873NICHD NIH HHS U10 HD063036
6 · The paper itself

Abstract

The National Institute of Child Health and Human Development's Nulliparous Pregnancy Outcomes Study-Monitoring Mothers-to-Be (nuMoM2b) Heart Health Study (HHS) was designed to investigate the relationships between adverse pregnancy outcomes and modifiable risk factors for cardiovascular disease. The ongoing nuMoM2b-HHS, which started in 2013, is a prospective follow-up of the nuMoM2b cohort, which included 10,038 women recruited between 2010 and 2013 from 8 centers across the United States who were initially observed over the course of their first pregnancies. In this report, we detail the design and study procedures of the nuMoM2b-HHS. Women in the pregnancy cohort who consented to be contacted for participation in future studies were approached at 6-month intervals to ascertain health information and to maintain ongoing contact. Two to 5 years after completion of the pregnancy documented in the nuMoM2b, women in the nuMoM2b-HHS were invited to an in-person study visit. During this visit, they completed psychosocial and medical history questionnaires and had clinical measurements and biological specimens obtained. A subcohort of participants who had objective assessments of sleep-disordered breathing during pregnancy were asked to repeat this investigation. This unique prospective observational study includes a large, geographically and ethnically diverse cohort, rich depth of phenotypic information about adverse pregnancy outcomes, and clinical data and biospecimens from early in the index pregnancy onward. Data obtained from this cohort will provide mechanistic and clinical insights into how data on a first pregnancy can provide information about the potential development of subsequent risk factors for cardiovascular disease.

Indexed as

PregnancyResearch DesignAdolescentAdultCardiovascular DiseasesFemaleFollow-Up StudiesHealth Status IndicatorsHumansPopulation SurveillancePregnancy OutcomeProspective StudiesRisk AssessmentRisk FactorsSleep Apnea SyndromesUnited Statescardiovascular diseasecohort studyheart healthmethodspregnancywomen's health

Identifiers

PMID26825925
PMCPMC4782765
OpenAlexW2300148139

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.