ArticleAddiction (Abingdon, England)2016
Assessing sample representativeness in randomized controlled trials: application to the National Institute of Drug Abuse Clinical Trials Network.
Article in Addiction (Abingdon, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Social Representativeness and Intervention Adherence-A Systematic Review of Clinical Physical Activity Trials in Breast Cancer Patients.International journal of public health · 2024Pooled it
- Addressing Systematic Missing Data in the Context of Causally Interpretable Meta-analysis.Prevention science : the official journal of the Society for Prevention Research · 2023Pooled it
- Calibrated meta-analysis to estimate the efficacy of mental health treatments in target populations: an application to paliperidone trials for treatment of schizophrenia.BMC medical research methodology · 2023Pooled it
- Ineligibility for and Refusal to Participate in Randomized Controlled Trials That Have Studied Impact on Suicide-Related Outcomes in the United States: A Meta-Analysis.The Journal of clinical psychiatry · 2022Pooled it
- Clinical Trial Generalizability Assessment in the Big Data Era: A Review.Clinical and translational science · 2020Pooled it
- Psilocybin in the Treatment of Cocaine Use Disorder: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Treatment Initiation, Substance Use Trajectories, and the Social Determinants of Health in Persons Living With HIV Seeking Medication for Opioid Use Disorder.Substance abuse · 2023Trial
- Estimating the impact of stimulant use on initiation of buprenorphine and extended-release naltrexone in two clinical trials and real-world populations.Addiction science & clinical practice · 2023Trial
- Predictors of Research Assessment Completion in a Latino Sample with Dual Disorders.Journal of immigrant and minority health · 2020Trial
- Generalizability of the findings from a randomized controlled trial of a web-based substance use disorder intervention.The American journal on addictions · 2018Trial
- Comparing adult cannabis treatment-seekers enrolled in a clinical trial with national samples of cannabis users in the United States.Drug and alcohol dependence · 2017Trial
- Use of multiple tobacco products in a national sample of persons enrolled in addiction treatment.Drug and alcohol dependence · 2016Trial
- Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data.BMC medicine · 2023Article
- Quantifying and reducing inequity in average treatment effect estimation.BMC medical research methodology · 2023Article
- Psychosocial Life Aspects among Substance Misuse Clients who are at Rehabilitation Phase: A Narrative Review.Health psychology research · 2023Article
- Under-representation of key demographic groups in opioid use disorder trials.Drug and alcohol dependence reports · 2022Article
- Transporting Subgroup Analyses of Randomized Controlled Trials for Planning Implementation of New Interventions.American journal of epidemiology · 2021Article
- 'Sick and tired': Patients reported reasons for not participating in clinical psychiatric research.Health expectations : an international journal of public participation in health care and health policy · 2021Article
- Target validity: Bringing treatment of external validity in line with internal validity.Current epidemiology reports · 2020Article
- Association of Medicaid Expansion and Health Insurance with Receipt of Smoking Cessation Services and Smoking Behaviors in Substance Use Disorder Treatment.The journal of behavioral health services & research · 2020Article
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5 authors.
Funding
Abstract
aimsTo compare the characteristics of individuals participating in randomized controlled trials (RCTs) of treatments of substance use disorder (SUD) with individuals receiving treatment in usual care settings, and to provide a summary quantitative measure of differences between characteristics of these two groups of individuals using propensity score methods. Design Analyses using data from RCT samples from the National Institute of Drug Abuse Clinical Trials Network (CTN) and target populations of patients drawn from the Treatment Episodes Data Set-Admissions (TEDS-A). Settings Multiple clinical trial sites and nation-wide usual SUD treatment settings in the United States.
participantsA total of 3592 individuals from 10 CTN samples and 1 602 226 individuals selected from TEDS-A between 2001 and 2009. Measurements The propensity scores for enrolling in the RCTs were computed based on the following nine observable characteristics: sex, race/ethnicity, age, education, employment status, marital status, admission to treatment through criminal justice, intravenous drug use and the number of prior treatments. Findings The proportion of those with ≥ 12 years of education and the proportion of those who had full-time jobs were significantly higher among RCT samples than among target populations (in seven and nine trials, respectively, at P < 0.001). The pooled difference in the mean propensity scores between the RCTs and the target population was 1.54 standard deviations and was statistically significant at P < 0.001.
conclusionsIn the United States, individuals recruited into randomized controlled trials of substance use disorder treatments appear to be very different from individuals receiving treatment in usual care settings. Notably, RCT participants tend to have more years of education and a greater likelihood of full-time work compared with people receiving care in usual care settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.