ArticleApplied microbiology and biotechnology2016
Effect of biosurfactants on Pseudomonas aeruginosa and Staphylococcus aureus biofilms in a BioFlux channel.
Article in Applied microbiology and biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Biosurfactants as Antibiofilm Agents for Medical Devices: Mechanisms, Evidence and Integration into Infection Prevention and Control.Microorganisms · 2026Review
- Review in Structure-Activity Relationships, Synthetic Regulation, and Applications of Mono/Di-Rhamnolipids.Microorganisms · 2026Review
- Lactonic sophorolipids byRSC advances · 2025Article
- Sophorolipid: An Effective Biomolecule for Targeting Microbial Biofilms.Current microbiology · 2024Review
- Rhamnolipid 89 Biosurfactant Is Effective againstInternational journal of molecular sciences · 2023Article
- Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications.Pharmaceutics · 2023Review
- Natural Medicine a Promising Candidate in Combating Microbial Biofilm.Antibiotics (Basel, Switzerland) · 2023Review
- Biotechnological potential of microbial bio-surfactants, their significance, and diverse applications.FEMS microbes · 2023Review
- The Multifunctional Role of Poloxamer P338 as a Biofilm Disrupter and Antibiotic Enhancer: A Small Step forward against the Big Trouble of Catheter-AssociatedMicroorganisms · 2022Article
- A review on the physicochemical and biological applications of biosurfactants in biotechnology and pharmaceuticals.Heliyon · 2022Review
- Biofilm Formation by Pathogenic Bacteria: Applying aPathogens (Basel, Switzerland) · 2022Review
- Comparison of inhibitory effects and mechanisms of lactonic sophorolipid on different pathogenic bacteria.Frontiers in microbiology · 2022Article
- Polymicrobial Interactions in the Cystic Fibrosis Airway Microbiome Impact the Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2021Review
- Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants.Pharmaceutics · 2021Review
- Recent advancements in the production of rhamnolipid biosurfactants byRSC advances · 2020Review
- Rhamnolipid exhibits anti-biofilm activity against the dermatophytic fungiBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Influence of biofilm growth age, media, antibiotic concentration and exposure time on Staphylococcus aureus and Pseudomonas aeruginosa biofilm removal in vitro.BMC microbiology · 2020Article
- Production of Mannosylerythritol Lipids (MELs) to be Used as Antimicrobial Agents Against S. aureus ATCC 6538.Current microbiology · 2020Article
- Inhibitory Effects of Lipopeptides and Glycolipids onFrontiers in microbiology · 2020Article
- Microscopic Investigation of the Combined Use of Antibiotics and Biosurfactants on Methicillin ResistantFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have indicated that biosurfactants play a role both in maintaining channels between multicellular structures in biofilms and in dispersal of cells from biofilms. A combination of caprylic acid (0.01 % v/v) together with rhamnolipids (0.04 % v/v) was applied to biofilms of Pseudomonas aeruginosa ATCC 15442, Staphylococcus aureus ATCC 9144 and a mixed culture under BioFlux flowthrough conditions and caused disruption of the biofilms. The biofilms were also treated with a combination of rhamnolipids (0.04 % v/v) and sophorolipids (0.01 %). Control treatments with PBS 1× had no apparent effect on biofilm disruption. The Gram-positive bacterium (S. aureus ATCC 9144) was more sensitive than P. aeruginosa ATCC 15442 in terms of disruption and viability as shown by Live/Dead staining. Disruption of biofilms of P. aeruginosa ATCC 15442 was minimal. Oxygen consumption by biofilms, after different treatments with biosurfactants, confirms that sophorolipid on its own is unable to kill/inhibit cells of P. aeruginosa ATCC 15442, and even when used in combination with rhamnolipids, under static conditions, no decrease in the cell viability was observed. Cells in biofilms exposed to mono-rhamnolipids (0.04 % v/v) showed behaviour typical of exposure to bacteriostatic compounds, but when exposed to di-rhamnolipids (0.04 % v/v), they displayed a pattern characteristic of bactericidal compounds.
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