SynthesisShock (Augusta, Ga.)2016
Prehospital Blood Product Resuscitation for Trauma: A Systematic Review.
Synthesis in Shock (Augusta, Ga.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04760977 (Prehospital Management of Hypotensive Trauma in HEMS), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prehospital Management of Hypotensive Trauma in HEMS
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Pre-hospital transfusion of red blood cells. Part 2: A systematic review of treatment effects on outcomes.Transfusion medicine (Oxford, England) · 2020Pooled it
- Pre-hospital management of mass casualty civilian shootings: a systematic literature review.Critical care (London, England) · 2016Pooled it
- Pre-hospital plasma in haemorrhagic shock management: current opinion and meta-analysis of randomized trials.World journal of emergency surgery : WJESPooled it
- Prehospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage.The journal of trauma and acute care surgery · 2022Trial
- Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial.The Lancet. Haematology · 2022Trial
- Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial.Lancet (London, England) · 2018Trial
- Association of time to red blood cell transfusion on outcomes in patients with gastrointestinal bleeding.Annals of medicine · 2025Article
- Prehospital blood for the injured in conflict zones: what about civilians? - a scoping review.Conflict and health · 2025Review
- Blood transfusion training for prehospital providers: a scoping review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Prehospital Blood Administration in Traumatic Hemorrhagic Shock.Journal of the American College of Emergency Physicians open · 2025Article
- First immediate transfusion at a prehospital environment in Latin America: A case report.Hematology, transfusion and cell therapy · 2023Article
- Prehospital predictors of the need for transfusion in patients with major trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Observational
- Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study.Critical care (London, England) · 2023Article
- Pre-hospital blood products and calcium replacement protocols in UK critical care services: A survey of current practice.Resuscitation plus · 2022Article
- Pre-hospital blood transfusion - an ESA survey of European practice.Scandinavian journal of trauma, resuscitation and emergency medicine · 2020Article
- Hemostatic agents for prehospital hemorrhage control: a narrative review.Military Medical Research · 2020Review
- Mortality of civilian patients with suspected traumatic haemorrhage receiving pre-hospital transfusion of packed red blood cells compared to pre-hospital crystalloid.Scandinavian journal of trauma, resuscitation and emergency medicine · 2018Observational
- Observational
- Efficacy of Uncross-Matched Type O Packed Red Blood Cell Transfusion to Traumatic Shock Patients: a Propensity Score Match Study.Journal of Korean medical science · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAdministration of high ratios of plasma to packed red blood cells is a routine practice for in-hospital trauma resuscitation. Military and civilian emergency teams are increasingly carrying prehospital blood products (PHBP) for trauma resuscitation. This study systematically reviewed the clinical literature to determine the extent to which the available evidence supports this practice.
methodsBibliographic databases and other sources were searched to July 2015 using keywords and index terms related to the intervention, setting, and condition. Standard systematic review methodology aimed at minimizing bias was used for study selection, data extraction, and quality assessment (protocol registration PROSPERO: CRD42014013794). Synthesis was mainly narrative with random effects model meta-analysis limited to mortality outcomes.
resultsNo prospective comparative or randomized studies were identified. Sixteen case series and 11 comparative studies were included in the review. Seven studies included mixed populations of trauma and non-trauma patients. Twenty-five of 27 studies provided only very low quality evidence. No association between PHBP and survival was found (OR for mortality: 1.29, 95% CI: 0.84-1.96, P = 0.24). A single study showed improved survival in the first 24 h. No consistent physiological or biochemical benefit was identified, nor was there evidence of reduced in-hospital transfusion requirements. Transfusion reactions were rare, suggesting the short-term safety of PHBP administration.
conclusionsWhile PHBP resuscitation appears logical, the clinical literature is limited, provides only poor quality evidence, and does not demonstrate improved outcomes. No conclusions as to efficacy can be drawn. The results of randomized controlled trials are awaited.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.