ArticleJournal of the American Society of Nephrology : JASN2016
IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition.
Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- IgA nephropathy new therapies: from data in adults to application in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- Serum IgE and IgA Levels in Pediatric Henoch-Schönlein Purpura: Clinical Characteristics and Immunological Correlations in the Context of Infectious Diseases-A Five-Year Retrospective Analysis.International journal of molecular sciences · 2025Article
- The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch-Schönlein Purpura: A Five-Year Retrospective Study.Biomedicines · 2025Article
- Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy.Frontiers in immunology · 2025Review
- Humoral immune responses primed by the alteration of gut microbiota were associated with galactose-deficient IgA1 production in IgA nephropathy.Frontiers in immunology · 2024Article
- Is There a Role for Gut Microbiome Dysbiosis in IgA Nephropathy?Microorganisms · 2022Review
- Are there animal models of IgA nephropathy?Seminars in immunopathology · 2021Review
- How will artificial intelligence and bioinformatics change our understanding of IgA Nephropathy in the next decade?Seminars in immunopathology · 2021Review
- History of IgA Nephropathy Mouse Models.Journal of clinical medicine · 2021Review
- Renal deposition and clearance of recombinant poly-IgA complexes in a model of IgA nephropathy.The Journal of pathology · 2021Article
- Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Fecal Microbiota Transplantation Modulates Renal Phenotype in the Humanized Mouse Model of IgA Nephropathy.Frontiers in immunology · 2021Article
- IgA nephropathy suspected to be combined with Fabry disease or Alport syndrome: a case report.The Journal of international medical research · 2020Article
- microRNA-630 Regulates Underglycosylated IgA1 Production in the Tonsils by Targeting TLR4 in IgA Nephropathy.Frontiers in immunology · 2020Article
- Mesangial Deposition Can Strongly Involve Innate-Like IgA Molecules Lacking Affinity Maturation.Journal of the American Society of Nephrology : JASN · 2019Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgA1 mesangial deposition is the hallmark of IgA nephropathy and Henoch-Schönlein purpura, the onset of which often follows infections. Deposited IgA has been reported as polymeric, J chain associated, and often, hypogalactosylated but with no information concerning the influence of the IgA repertoire or the link between immune stimuli and IgA structure. We explored these issues in the α1KI mouse model, which produces polyclonal human IgA1 prone to mesangial deposition. Compared with mice challenged by a conventional environment, mice in a specific pathogen-free environment had less IgA deposition. However, serum IgA of specific pathogen-free mice showed more galactosylation and much lower polymerization. Notably, wild-type, α1KI, and even J chain-deficient mice showed increased polymeric serum IgA on exposure to pathogens. Strict germfree conditions delayed but did not completely prevent deposition; mice housed in these conditions had very low serum IgA levels and produced essentially monomeric IgA. Finally, comparing monoclonal IgA1 that had different variable regions and mesangial deposition patterns indicated that, independently of glycosylation and polymerization, deposition might also depend on IgA carrying specific variable domains. Together with IgA quantities and constant region post-translational modifications, repertoire changes during immune responses might, thus, modulate IgA propensity to deposition. These IgA features are not associated with circulating immune complexes and C3 deposition and are more pertinent to an initial IgA deposition step preceding overt clinical symptoms in patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.