ArticleUrology2016
Incidence and Management of Uncomplicated Recurrent Urinary Tract Infections in a National Sample of Women in the United States.
Article in Urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04108910 (Reduction in Morbidity Rate for Urinary Tract Infections Through Use of PCR-Based Diagnosis and Management), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reduction in Morbidity Rate for Urinary Tract Infections Through Use of PCR-Based Diagnosis and Management
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Global Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.Clinical microbiology reviews · 2019Pooled it
- Feasibility and Research Insights From a Randomized Controlled Trial for Recurrent Urinary Tract Infection Prevention in Postmenopausal Women Using Vaginal Estrogen Therapy.Female pelvic medicine & reconstructive surgery · 2022Trial
- Characterization of isolates from two phase 3 uncomplicated urinary tract infection trials (EAGLE-2 and EAGLE-3) that show an apparent ≥4-fold increase in gepotidacin MIC between baseline and post-baseline visits.JAC-antimicrobial resistance · 2026Article
- Efficacy ofClinics and practice · 2026Article
- Current Scientific Advances in Vaccines Against UTIs: Challenges and Prospects.Microorganisms · 2025Review
- State-of-the-Art Review: Recurrent Uncomplicated Urinary Tract Infections in Women.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Review
- Immunoprophylaxis with MV140 Is Effective in the Reduction of Urinary Tract Infections-A Prospective Real-Life Study.Vaccines · 2024Article
- Recurrent urinary tract infections and prophylactic antibiotic use in women: a cross-sectional study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- Antibiotic-Sparing Prevention of Urinary Tract Infections-New Evidence Regarding d-Mannose.JAMA internal medicine · 2024Article
- The Percentage of Antibiotic Resistance in Uncomplicated Community-Acquired Urinary Tract Infections.Deutsches Arzteblatt international · 2024Observational
- Prediction of Antibiotic Resistance in Patients With a Urinary Tract Infection: Algorithm Development and Validation.JMIR medical informatics · 2024Article
- Article
- The Possible Role of Probiotic Supplementation in Inflammation: A Narrative Review.Microorganisms · 2023Review
- Biofilm Lifestyle in Recurrent Urinary Tract Infections.Life (Basel, Switzerland) · 2023Review
- Effects of aging on urinary tract epithelial homeostasis and immunity.Developmental biology · 2023Review
- Virulence Mechanisms of Common Uropathogens and Their Intracellular Localisation within Urothelial Cells.Pathogens (Basel, Switzerland) · 2022Article
- Factors Associated With a Positive Urine Culture in Women Seeking Urogynecologic Care for Urinary Tract Infection Symptoms.Female pelvic medicine & reconstructive surgery · 2022Article
- Incidence of urosepsis or pyelonephritis after uncomplicated urinary tract infection in older women.International urogynecology journal · 2022Article
- A systematic review of the outcomes reported in the treatment of uncomplicated urinary tract infection clinical trials.JAC-antimicrobial resistance · 2022Review
- Characteristics Associated With Repeated Evaluations for Urinary Tract Infections in Older Women: A Case-Control Study.Female pelvic medicine & reconstructive surgery · 2022Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo determine the incidence and characteristics of women with uncomplicated recurrent urinary tract infections (UTIs) and to explore whether the use of culture-driven treatment affects rates of UTI-related complications and resource utilization. MATERIALS AND
methodsUsing MarketScan claims from 2003 to 2011, we identified UTI-naive women ages 18-64 with incident-uncomplicated recurrent UTIs. Recurrent UTIs were defined as 3 UTI visits associated with antibiotics during a 12-month period. Cases were excluded if they had a UTI in the preceding year, or if they had any complicating factors (eg, abnormality of the urinary tract, neurologic condition, pregnancy, diabetes, or currently taking immunosuppression). We next assessed use of urine cultures, imaging, and cystoscopy, and performed propensity score matching with logistic regression to determine whether having a urine culture associated with >50% of UTIs affected rates of complications and downstream resource utilization.
resultsWe identified 48,283 women with incident-uncomplicated recurrent UTIs, accounting for an overall incidence of 102 per 100,000 women, highest among women ages 18-34 and 55-64. Sixty-one percent of these women had at least 1 urine culture, 6.9% had imaging, and 2.8% had cystoscopy. Having a urine culture >50% of the time was associated with fewer UTI-related hospitalizations and lower rates of intravenous antibiotic use, whereas demonstrating higher rates of UTI-related office visits and pyelonephritis.
conclusionThe incidence of uncomplicated recurrent UTIs increases with age. Urine culture-directed care is beneficial in reducing high-cost services including UTI-related hospitalizations and intravenous antibiotic use, making urine cultures a valuable component to management of these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.