Evidence map›Paper›PMID 26825392›Full record

ArticleDevelopmental biology2016

Eric Davidson: Steps to a gene regulatory network for development.

Ellen V Rothenberg

Abstract readBiographyEditorialHistorical Article
In one paragraph

Article in Developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. From Gregor Mendel to Eric Davidson: Mathematical Models and Basic Principles in Biology.Journal of computational biology : a journal of computational molecular cell biology · 2019
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Ellen V RothenbergDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: evroth@its.caltech.edu.

Funding

LINEAGE COMMITMENT MECHANISMS IN LYMPHOID PRECURSORSR01CA090233 · NCI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROTHENBERG, ELLEN V. · 2001 to 2011
$3.9M
Kinetic modeling and single-cell molecular mechanisms of early T-cell commitmentR01HL119102 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PETERSON, CARSTEN, ROTHENBERG, ELLEN V. · 2014 to 2018
$3.0M
Genomic site binding rules and regulatory factor function in developing T cellsR01HD076915 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROTHENBERG, ELLEN V. · 2013 to 2017
$2.5M
LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTESR01AG013108 · NIA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROTHENBERG, ELLEN V. · 1995 to 2004
$1.6M
Reverse engineering genetic network architecture of stem-cell/lymphocyte transitiR33HL089123 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROTHENBERG, ELLEN V. · 2007 to 2009
$1.6M
NCI NIH HHS R01 CA090233NCI NIH HHS R01CA090233NHLBI NIH HHS R01 HL119102NHLBI NIH HHS R01HL119102NHLBI NIH HHS R33 HL089123NHLBI NIH HHS R33HL089123NIA NIH HHS R01 AG013108NIA NIH HHS R01AG013108NICHD NIH HHS R01 HD076915
6 · The paper itself

Abstract

Eric Harris Davidson was a unique and creative intellectual force who grappled with the diversity of developmental processes used by animal embryos and wrestled them into an intelligible set of principles, then spent his life translating these process elements into molecularly definable terms through the architecture of gene regulatory networks. He took speculative risks in his theoretical writing but ran a highly organized, rigorous experimental program that yielded an unprecedentedly full characterization of a developing organism. His writings created logical order and a framework for mechanism from the complex phenomena at the heart of advanced multicellular organism development. This is a reminiscence of intellectual currents in his work as observed by the author through the last 30-35 years of Davidson's life.

Indexed as

Gene Regulatory NetworksAnimalsCell BiologyCell LineageDevelopmental BiologyHistory, 20th CenturyHistory, 21st CenturySea Urchins

Identifiers

PMID26825392
PMCPMC4828313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.