Evidence map›Paper›PMID 26825350›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2016

Parathyroid Hormone and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging Study.

Sai Krishna C Korada, Di Zhao, Rebecca F Gottesman, Eliseo Guallar, Pamela L Lutsey, Alvaro Alonso, A Richey Sharrett, Wendy S Post, Jared P Reis, Thomas H Mosley and 1 more

Abstract read
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In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Serum magnesium, bone-mineral metabolism markers and their interactions with kidney function on subsequent risk of peripheral artery disease: the Atherosclerosis Risk in Communities Study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Article
  6. Observational
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sai Krishna C KoradaNortheast Ohio Medical University, Rootstown, Ohio.
Di ZhaoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Rebecca F GottesmanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Eliseo GuallarDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Pamela L LutseyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, St. Paul, Minnesota.
Alvaro AlonsoDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, St. Paul, Minnesota.
A Richey SharrettDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Wendy S PostDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland.
Jared P ReisDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Thomas H MosleyDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Erin D MichosDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address: edonnell@jhmi.edu.

Funding

The ARIC and Neurocognitive Longitudinal StudyR01HL070825 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI MOSLEY, THOMAS H · 2002 to 2004
$5.1M
Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC CohortR01HL103706 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2011 to 2014
$2.3M
Summer Research Training in Aging for Medical StudentsT35AG026758 · NIA · JOHNS HOPKINS UNIVERSITY · PI Stephanie Nothelle, Sevil Yasar · 2005 to 2026
$1.9M
Vitamin D, cerebrovascular risk, and neurocognitive decline: ARIC Brain MRI StudyR01NS072243 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MICHOS, ERIN D · 2011 to 2014
$1.4M
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01-HL70825NIA NIH HHS T35 AG026758NINDS NIH HHS R01 NS072243NINDS NIH HHS R01NS072243
6 · The paper itself

Abstract

backgroundElevated parathyroid hormone (PTH) levels have been associated with cardiovascular disease risk factors and events. We hypothesized that elevated PTH levels would also be associated with subclinical cerebrovascular disease. We examined the relationship between elevated PTH level and white matter hyperintensities (WMHs) and subclinical infarcts measured on brain magnetic resonance imaging (MRI).

methodsPTH was measured at baseline (1993-1994) among participants free of prior clinical stroke who underwent a brain MRI at baseline (n = 1703) and a second brain MRI 10 years later (n = 948). PTH levels of 65 pg/mL or higher were considered elevated (n = 204). Participants who did not return for a follow-up MRI had, at baseline, higher PTH and a greater prevalence of cardiovascular risk factors (P < .05 for all); therefore, multiple imputation was used. The cross-sectional and prospective associations of PTH levels with WMH and MRI-defined infarcts (and their progression) were investigated using multivariable regression models.

resultsAt baseline, the participants had a mean age of 62 years and were 60% female and 49% black. Cross-sectionally, after adjusting for demographic and lifestyle factors, elevated PTH level was associated with higher WMH score (β = .19, 95% confidence interval [CI] .04-.35) and increased odds of prevalent infarcts (odds ratio 1.56, 95% CI 1.02-2.36). Results were attenuated after adjustment for potential mediators of this association (i.e., hypertension). No prospective associations were found between PTH and incident infarcts or change in estimated WMH volume, although estimates were imprecise.

conclusionsAlthough associated cross-sectionally, we did not confirm any association between elevated PTH level and progression of cerebrovascular changes on brain MRIs obtained 10 years apart. The relationship of PTH with subclinical brain disease warrants further study.

Indexed as

Magnetic Resonance ImagingBrainCerebrovascular DisordersCohort StudiesCross-Sectional StudiesFemaleHumansImage Processing, Computer-AssistedLeukoencephalopathiesMaleMiddle AgedParathyroid HormoneParathyroid Hormonebrain MRIcerebrovascular diseaseParathyroid hormonesubclinical brain infarctswhite matter hyperintensities

Identifiers

PMID26825350
PMCPMC4799747

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.