Evidence map›Paper›PMID 26825177›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2016

HIV Community Viral Load and Factors Associated With Elevated Viremia Among a Community-Based Sample of Men Who Have Sex With Men in Vancouver, Canada.

David M Moore, Zishan Cui, Nathan Lachowsky, Henry F Raymond, Eric Roth, Ashleigh Rich, Paul Sereda, Terry Howard, Willi McFarland, Allan Lal and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  7. Overamped: Stimulant Use and HIV Pathogenesis.Current HIV/AIDS reports · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

David M Moore*Department of Medicine, University of British Columbia, Vancouver, Canada; †BC Centre for Excellence in HIV/AIDS, Vancouver, Canada; ‡University of California San Francisco, San Francisco, CA; §University of Victoria, Victoria, Canada; ‖Positive Living Society of BC, Vancouver, Canada; ¶Interior Health, Kelowna, Canada; and #Simon Fraser University, Burnaby, Canada.
Zishan Cui
Nathan Lachowsky
Henry F Raymond
Eric Roth
Ashleigh Rich
Paul Sereda
Terry Howard
Willi McFarland
Allan Lal
Julio Montaner
Trevor Corneil
Robert S Hogg
Momentum Health Study team
National Institute on Drug Abuse · US

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Seek and Treat for Optimal Prevention of HIV & AIDS (STOP HIV/AIDS) in BCR01DA036307 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI MONTANER, JULIO SERGIO GONZALEZ · 2013 to 2017
$3.0M
HAART optimism, drug use and risky sexual behavior among MSM in British Columbia.R01DA031055 · NIDA · SIMON FRASER UNIVERSITY · PI HOGG, ROBERT S · 2011 to 2015
$2.0M
Canadian Institutes of Health Research MOP-107544NIDA NIH HHS R01 DA031055NIDA NIH HHS R01DA031055-01A1NIDA NIH HHS R01 DA036307NIDA NIH HHS R01DA036307NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

backgroundWe developed estimates of community viral load (VL) and risk factors for unsuppressed VL from a cross-sectional study of men who have sex with men (MSM) in Vancouver, Canada.

methodsMSM were recruited from February 25, 2012 to February 28, 2014 using respondent-driven sampling (RDS). Participants completed a computer-assisted self-interview questionnaire and a nurse-administered point-of-care HIV test. For HIV-positive participants, we conducted VL and CD4 cell counts. We used RDS-weighted analysis to obtain population estimates of key variables and multivariable logistic regression to examine factors associated with having a VL of ≥200 copies per milliliter among HIV-positive participants.

resultsWe recruited 719 participants, of whom 119 (16.6%) were seeds. Our estimate of the population prevalence of HIV was 23.4% [95% confidence interval (CI): 15.8% to 31.0%] after RDS adjustments. We estimated that 18.6% (95% CI: 8.8% to 30.4%) of HIV-positive MSM in Vancouver had a VL of ≥200 copies per milliliter. Having an unsuppressed VL was associated with non-white ethnicity [adjusted odds ratio (AOR) = 4.34; 95% CI: 1.67 to 11.1], an annual income of <$15,000 CAD (AOR = 6.43; 95% CI: 2.08 to 19.9), using gamma-hydroxy butyrate in the previous 6 months (AOR = 4.85; 95% CI: 1.79 to 13.2), unprotected anal intercourse with a known HIV-negative or an unknown serostatus partner (AOR = 3.13; 95% CI: 1.10 to 8.90), and disclosing one's HIV serostatus ≥50% of the time (AOR = 7.04; 95% CI: 1.01 to 49.1).

conclusionDespite a high prevalence of HIV, we estimated that a small proportion of HIV-positive MSM have undiagnosed HIV and unsuppressed VL. Our results highlight the importance of continued work to address health inequities using a framework based on social determinants of health.

Indexed as

HIV-1Viral LoadAdultCanadaCD4 Lymphocyte CountCross-Sectional StudiesHIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedRisk FactorsRisk-TakingSexual BehaviorSexual PartnersSubstance-Related Disorders

Identifiers

PMID26825177
PMCPMC4837069
OpenAlexW2318821245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.