Evidence map›Paper›PMID 26824990›Full record

ArticleOncotarget2016

The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial.

Yongzhi Yang, Yang Xia, Hongqi Chen, Leiming Hong, Junlan Feng, Jun Yang, Zhe Yang, Chenzhang Shi, Wen Wu, Renyuan Gao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 15 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Trial
  17. Review
  18. Review
  19. Review
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yongzhi YangDepartment of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Yang XiaDepartment of Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Hongqi ChenDepartment of Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Leiming HongDepartment of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Junlan FengDepartment of Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Jun YangDepartment of Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Zhe YangDepartment of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Chenzhang ShiDepartment of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Wen WuDepartment of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Renyuan GaoDepartment of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Qing WeiDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Huanlong QinDepartment of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Yanlei MaDepartment of GI Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to mainly evaluate the anti-infective effects of perioperative probiotic treatment in patients receiving confined colorectal cancer (CRC) respective surgery. From November 2011 to September 2012, a total of 60 patients diagnosed with CRC were randomly assigned to receive probiotic (n = 30) or placebo (n = 30) treatment. The operative and post-operative clinical results including intestinal cleanliness, days to first - flatus, defecation, fluid diet, solid diet, duration of pyrexia, average heart rate, length of intraperitoneal drainage, length of antibiotic therapy, blood index changes, rate of infectious and non-infectious complications, postoperative hospital stay, and mortality were investigated. The patient demographics were not significantly different (p > 0.05) between the probiotic treated and the placebo groups. The days to first flatus (3.63 versus 3.27, p = 0.0274) and the days to first defecation (4.53 versus 3.87, p = 0.0268) were significantly improved in the probiotic treated patients. The incidence of diarrhea was significantly lower (p = 0.0352) in probiotics group (26.67%, 8/30) compared to the placebo group (53.33%, 16/30). There were no statistical differences (p > 0.05) in other infectious and non-infectious complication rates including wound infection, pneumonia, urinary tract infection, anastomotic leakage, and abdominal distension. In conclusion, for those patients undergoing confined CRC resection, perioperative probiotic administration significantly influenced the recovery of bowel function, and such improvement may be of important clinical significance in reducing the short-term infectious complications such as bacteremia.

Indexed as

Perioperative CareAdultAgedAged, 80 and overBacteremiaCase-Control StudiesColorectal NeoplasmsDigestive System Surgical ProceduresFemaleFollow-Up StudiesHumansLength of StayMaleMiddle AgedNeoplasm StagingProbioticscolorectal cancerperioperative probiotics treatmentpost-operative outcomerandomised clinical trial

Identifiers

PMID26824990
PMCPMC4885004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.