ArticlePloS one2016
Comparative Analysis of Genome Diversity in Bullmastiff Dogs.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Measures of Homozygosity and Relationship to Genetic Diversity in the Bearded Collie Breed.Genes · 2025Article
- The Demography, Longevity and Mortality of Bullmastiffs Attending Veterinary Practices in Australia.Animals : an open access journal from MDPI · 2024Article
- Genomic Analysis of Lymphoma Risk in Bullmastiff Dogs.Veterinary sciences · 2023Article
- Lymphoma in Border Collies: Genome-Wide Association and Pedigree Analysis.Veterinary sciences · 2023Article
- Homozygosity mapping in the Kazakh national dog breed Tazy.Scientific reports · 2023Article
- Identification of Genomic Signatures in Bullmastiff Dogs Using Composite Selection Signals Analysis of 23 Purebred Clades.Animals : an open access journal from MDPI · 2023Article
- Article
- Evaluation of genetic diversity and management of disease in Border Collie dogs.Scientific reports · 2021Article
- Genomic Characterization of the Istrian Shorthaired Hound.Animals : an open access journal from MDPI · 2020Article
- A Genomic Study of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels.Animals : an open access journal from MDPI · 2020Article
- Analysis of Genetic Diversity in the Czech Spotted Dog.Animals : an open access journal from MDPI · 2020Article
- The German Shorthair Pointer Dog Breed (Animals : an open access journal from MDPI · 2020Article
- Variation in breeding practices and geographic isolation drive subpopulation differentiation, contributing to the loss of genetic diversity within dog breed lineages.Canine medicine and genetics · 2020Article
- Genetic diversity and population structure of the Sapsaree, a native Korean dog breed.BMC genetics · 2019Article
- Tracing genetic resurrection of pointing dog breeds: Cesky Fousek as both survivor and rescuer.PloS one · 2019Article
- Studies of modern Italian dog populations reveal multiple patterns for domestic breed evolution.Ecology and evolution · 2018Article
- Genome-wide diversity and runs of homozygosity in the "Braque Français, type Pyrénées" dog breed.BMC research notes · 2018Article
- Genomic characterization of the Braque Français type Pyrénées dog and relationship with other breeds.PloS one · 2018Article
- Origins and wanderings of the Finnish hunting spitzes.PloS one · 2018Article
- Genomic data illuminates demography, genetic structure and selection of a popular dog breed.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Management and preservation of genomic diversity in dog breeds is a major objective for maintaining health. The present study was undertaken to characterise genomic diversity in Bullmastiff dogs using both genealogical and molecular analysis. Genealogical analysis of diversity was conducted using a database consisting of 16,378 Bullmastiff pedigrees from year 1980 to 2013. Additionally, a total of 188 Bullmastiff dogs were genotyped using the 170,000 SNP Illumina CanineHD Beadchip. Genealogical parameters revealed a mean inbreeding coefficient of 0.047; 142 total founders (f); an effective number of founders (fe) of 79; an effective number of ancestors (fa) of 62; and an effective population size of the reference population of 41. Genetic diversity and the degree of genome-wide homogeneity within the breed were also investigated using molecular data. Multiple-locus heterozygosity (MLH) was equal to 0.206; runs of homozygosity (ROH) as proportion of the genome, averaged 16.44%; effective population size was 29.1, with an average inbreeding coefficient of 0.035, all estimated using SNP Data. Fine-scale population structure was analysed using NETVIEW, a population analysis pipeline. Visualisation of the high definition network captured relationships among individuals within and between subpopulations. Effects of unequal founder use, and ancestral inbreeding and selection, were evident. While current levels of Bullmastiff heterozygosity, inbreeding and homozygosity are not unusual, a relatively small effective population size indicates that a breeding strategy to reduce the inbreeding rate may be beneficial.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.