Evidence map›Paper›PMID 26824501›Full record

ArticleOncotarget2016

SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma.

Yulan Wang, Ran Cui, Xiao Zhang, Yongxia Qiao, Xiangfan Liu, Yefei Chang, Yongchun Yu, Fenyong Sun, Jiayi Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. The Potential of Superoxide Dismutase-RichInternational journal of molecular sciences · 2025
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  15. Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: From mouse to human.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Yulan WangDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, 200072, China.
Ran CuiDepartment of Oncology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, 200072, China.
Xiao ZhangDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, 200072, China.
Yongxia QiaoSchool of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Xiangfan LiuFaculty of Medical Laboratory Science, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Yefei ChangDepartment of Clinical Laboratory Medicine, Third People's Hospital of Yunnan Province, Kunming, 650011, Yunnan Province, China.
Yongchun YuShanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai TCM University, Shanghai, 200071, China.
Fenyong SunDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, 200072, China.
Jiayi WangDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, 200072, China.
Tongji University · CNShanghai Jiao Tong University · CNShanghai Tenth People's Hospital · CNShanghai University of Traditional Chinese Medicine · CNThird People's Hospital of Yunnan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both oncoprotein and tumor-suppressor activity have been reported for SIRTUIN1 (SIRT1) and p38 in many types of cancer. The effect of SIRT1 on p38 phosphorylation (p-p38) remains controversial and may be organ- and cell-specific. We found that SIRT1 is essential for maintaining liver size and weight in mice. SIRT1 levels were elevated in human HCC compared to adjacent normal liver tissue, and its expression correlated positively with p-p38 levels. Additionally, SIRT1-activated p38 increased liver cancer malignancy. SIRT1 increased phosphorylation and nuclear accumulation of p38, possibly by increasing MKK3 expression. SIRT1 also induced YAP expression, which in turn increased MKK3 transcription. Positive correlations between SIRT1, YAP, MKK3, and p-p38 levels indicate that blocking their activity may prove helpful in treating HCC.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCarcinoma, HepatocellularCell Cycle ProteinsDisease Models, AnimalHumansLiverLiver NeoplasmsMAP Kinase Kinase 3MiceMice, Inbred C57BLMice, KnockoutMice, Transgenicp38 Mitogen-Activated Protein KinasesPhosphoproteinsPhosphorylationAdaptor Proteins, Signal TransducingCell Cycle ProteinsMAP2K3 protein, humanMap2k3 protein, mouseMAP Kinase Kinase 3p38 Mitogen-Activated Protein KinasesPhosphoproteinsSIRT1 protein, humanSirt1 protein, mouseSirtuin 1Transcription FactorsYAP1 protein, humanYap1 protein, mouseYAP-Signaling Proteinscell proliferationliver cancerpromoterRNA polymerase IIsurvival

Identifiers

PMID26824501
PMCPMC4905473
OpenAlexW2269176680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.