ArticleOrganic letters2016
Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles.
Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Advances in Piperazine-based Compounds for Antimicrobial Drug Development: Design, SAR, and Therapeutic Potential.Current drug research reviews · 2026Review
- Recent advances in non-conventional synthesis of N-heterocyclic compounds: emerging strategies and biological perspectives.RSC advances · 2025Review
- Synthesis of Substituted 1,4-Benzodiazepines by Palladium-Catalyzed Cyclization ofMolecules (Basel, Switzerland) · 2025Article
- Synthetic Protocols, Structural Activity Relationship, and Biological Activity of Piperazine and its Derivatives.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024Review
- Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry.RSC advances · 2020Review
- Enantioselective synthesis ofChemical science · 2019Article
- Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes.Nature communications · 2018Article
- Copper-catalyzed [1,2]-rearrangements of allylic iodides and aryl α-diazoacetates.Tetrahedron · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.
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Registered trials
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