ArticlePhysical biology2016
Excitable waves and direction-sensing in Dictyostelium discoideum: steps towards a chemotaxis model.
Article in Physical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells.PLoS computational biology · 2021Article
- Spatial gradient sensing and chemotaxis via excitability in Dictyostelium discoideum.Physical review. E · 2020Article
- The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation.Scientific reports · 2020Article
- The threshold of an excitable system serves as a control mechanism for noise filtering during chemotaxis.PloS one · 2018Article
- A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation.PLoS biology · 2017Article
- Relaxation oscillations and hierarchy of feedbacks in MAPK signaling.Scientific reports · 2017Article
- Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance.PLoS computational biology · 2016Article
- Self-organization of chemoattractant waves in Dictyostelium depends on F-actin and cell-substrate adhesion.Journal of the Royal Society, Interface · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In recent years, there have been significant advances in our understanding of the mechanisms underlying chemically directed motility by eukaryotic cells such as Dictyostelium. In particular, the local excitation and global inhibition (LEGI) model has proven capable of providing a framework for quantitatively explaining many experiments that present Dictyostelium cells with tailored chemical stimuli and monitor their subsequent polarization. In their natural setting, cells generate their own directional signals via the detection and secretion of cyclic adenosine monophosphate (cAMP). Here, we couple the LEGI approach to an excitable medium model of the cAMP wave-field that is propagated by the cells and investigate the possibility for this class of models to enable accurate chemotaxis to the cAMP waveforms expected in vivo. Our results indicate that the ultra-sensitive version of the model does an excellent job in providing natural wave rectification, thereby providing a compelling solution to the 'back-of-the-wave paradox' during cellular aggregation.
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Registered trials
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