ArticleActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2015
Analysis of risk factors for pharyngocutaneous fistula after total laryngectomy with particular focus on nutritional status.
Article in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pharyngocutaneous fistula following total laryngectomy: a systematic review of risk factors and management strategies (2010-2024).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- Role of cervical fascia flap in reducing the incidence of pharyngocutaneous fistula after total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Trial
- Stapler versus conventional pharyngeal repair after total laryngectomy: a randomized clinical trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Trial
- Effect of individualized nutritional intervention on head and neck cancer patients receiving radiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Trial
- Platelet-rich fibrin: an autologous biomaterial for healing assistance of pharyngeal repair in total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Trial
- Pharyngeal and Cervical Reconstruction and Fistula Management Following Total Laryngectomy: Contemporary Strategies and Evidence.Life (Basel, Switzerland) · 2026Review
- Prognostic significance of nutritional and inflammatory markers in locoregional advanced laryngeal cancer undergoing total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Investigating the effects of vitamin C administration on the incidence of pharyngocutaneous fistulas after total laryngectomy: a randomized controlled trial.Annals of medicine and surgery (2012) · 2025Article
- Effects of Myroxylon pereirae, Phenytoin, and Clinoptilolite After Pharyngocutaneous Fistula: An Experimental Animal Model.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Results of Platelet-Rich Fibrin Application in Pharyngeal Reconstruction After a Total Laryngectomy.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Article
- Prognostic value of serum 25-hydroxyvitamin D levels and malnutrition status on postoperative complications in patients following laryngectomy with neck dissection.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The total amount of fluid administered is associated with postoperative complications in head and neck cancer surgery.World journal of otorhinolaryngology - head and neck surgery · 2023Article
- Enhanced recovery after surgery, current, and future considerations in head and neck cancer.Laryngoscope investigative otolaryngology · 2023Review
- Pharyngocutaneous Fistula Following Total Laryngectomy: a High-Volume Tertiary Centre Series.Indian journal of surgical oncology · 2023Article
- Pectoralis Major in Salvage Total Laryngectomy after Irradiation: Morbidity, Mortality, Functional, and Oncological Results in a Referral Center in Egypt.Journal of personalized medicine · 2023Article
- Risk Factors for Pharyngocutaneous Fistula Following Total Laryngectomy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Evaluation of the Incidence of Pharyngocutaneous Fistula after Total Laryngectomy.Iranian journal of otorhinolaryngology · 2023Article
- Meta-analysis of risk factors associated with pharyngocutaneous fistulas following total laryngectomy.American journal of translational research · 2023Review
- Factors predicting pharyngocutaneous fistula in patients after salvage laryngectomy for laryngeal malignancy - A multicenter collaborative cohort study.Oral oncology · 2022Article
- Botulinum Neurotoxin A in the Treatment of Pharyngocutaneous Fistula after Salvage Surgery in Head and Neck Cancer Patients: Our Preliminary Results.Current oncology (Toronto, Ont.) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharyngocutaneous fistula (PCF) is the most common complication following total laryngectomy and the most difficult to manage. It often causes increased morbidity, delays starting adjuvant therapy, prolongs hospitalisation, increases treatment costs and reduces the quality of life (QoL). The objective of this study is to analyse the predisposing factors and the most important nutritional parameters related to the development of PCF in patients undergoing total laryngectomy and to suggest medical alternatives that might improve results. We performed a retrospective study of 69 patients who underwent either primary or salvage total laryngectomy in our department between January 2008 and January 2012. Risk factors for fistula formation were analysed including tumour characteristics (histology, grading, AJCC stage), treatment (primary or salvage surgery, extent of resection, flap reconstruction, preoperative radiotherapy), comorbidity and nutritional status (preoperative haemoglobin, albumin and prealbumin levels and their changes during hospitalisation). Twenty-four patients developed a PCF (overall incidence 34.8%). Fistula formation was significantly higher in patients with diabetes, preoperative malnutrition (identified from low preoperative albumin and prealbumin levels). After specific nutritional evaluation and support, no patient developed a PCF. Risk factors for PCF formation are extensively treated in the literature but identification of high-risk patients is still controversial. Our study demonstrates that nutritional status of the patient, assessed by preoperative albumin, is also an important risk factor for PCF formation in addition to classical factors. Maintenance of a normal perioperative nutritional status can be helpful to avoid this complication.
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26824210PMC4731886W2181267015What OpenQuestion holds
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