Evidence map›Paper›PMID 26824043›Full record

ArticleJournal of diabetes research2016

A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria.

Yildiz Tutuncu, Ilhan Satman, Selda Celik, Nevin Dinccag, Kubilay Karsidag, Aysegul Telci, Sema Genc, Halim Issever, Jaakko Tuomilehto, Beyhan Omer

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 4 countries.

Yildiz TutuncuDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Ilhan SatmanDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Selda CelikDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Nevin DinccagDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Kubilay KarsidagDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Aysegul TelciDepartment of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Sema GencDepartment of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Halim IsseverDepartment of Public Health, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Jaakko TuomilehtoCentre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria; Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Beyhan OmerDepartment of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey.
Istanbul University · TRUniversität für Weiterbildung Krems · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order to simplify the diagnostic tests compared with the 2-hour oral glucose tolerance test (OGTT; 2-hPG). We aimed to identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) in new-onset DM people based on FPG, 2-hPG, or HbA1c methods. Data derived from recent population-based survey in Turkey (TURDEP-II). The study included 26,499 adult people (63% women, response rate 85%). The mean serum concentration of hs-CRP in women was higher than in men (p < 0.001). The people with new-onset DM based on HbA1c had higher mean hs-CRP level than FPG based and 2-hPG based DM cases. In HbA1c, 2-hPG, and FPG based new-onset DM people, cut-off levels of hs-CRP in women were 2.9, 2.1, and 2.5 mg/L [27.5, 19.7, and 23.5 nmol/L] and corresponding values in men were 2.0, 1.8, and 1.8 mg/L (19.0, 16.9, and 16.9 nmol/L), respectively (sensitivity 60-65% and specificity 54-64%). Our results revealed that hs-CRP may not further strengthen the diagnosis of new-onset DM. Nevertheless, the highest hs-CRP level observed in new-onset DM people diagnosed with HbA1c criterion supports the general assumption that this method might recognize people in more advanced diabetic stage compared with other diagnostic methods.

Indexed as

Glucose Tolerance TestAdultArea Under CurveBiomarkersBlood GlucoseC-Reactive ProteinDiabetes MellitusFastingFemaleGlycated HemoglobinHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsROC CurveBiomarkersBlood GlucoseC-Reactive ProteinGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID26824043
PMCPMC4707339
OpenAlexW2212999377

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.