Evidence map›Paper›PMID 26824034›Full record

ArticleBioMed research international2015

Validation of Urine Test for Detection of Helicobacter pylori Infection in Indonesian Population.

Ari Fahrial Syam, Muhammad Miftahussurur, Willy Brodus Uwan, David Simanjuntak, Tomohisa Uchida, Yoshio Yamaoka

Open access · hybridAbstract readValidation Study
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Urinary metabolic profiles duringWorld journal of clinical cases · 2024
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  3. Overview ofGut and liver · 2021
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  4. Diagnostic Value ofClinical and experimental gastroenterology · 2021
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  7. Observation of Changes inInternational journal of general medicine · 2020
    Article
  8. Article
  9. Cost-Effectiveness Analysis ofGastroenterology research and practice · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Ari Fahrial SyamDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia.
Muhammad MiftahussururDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan; Gastroentero-Hepatology Division, Department of Internal Medicine, Airlangga University Faculty of Medicine, Surabaya 60131, Indonesia; Institute of Tropical Disease, Airlangga University, Surabaya 60115, Indonesia.
Willy Brodus UwanDepartment of Internal Medicine, Santo Antonius Hospital, Pontianak 78115, Indonesia.
David SimanjuntakDepartment of Internal Medicine, Yowari Hospital, Jayapura 99352, Indonesia.
Tomohisa UchidaDepartment of Molecular Pathology, Oita University Faculty of Medicine, Yufu 879-5593, Japan.
Yoshio YamaokaDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan; Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA.
Oita University · JPBaylor College of Medicine · USUniversity of Indonesia · ID

Funding

REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORIR01DK062813 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI YAMAOKA, YOSHIO · 2004 to 2013
$3.0M
NIDDK NIH HHS DK62813NIDDK NIH HHS R01 DK062813
6 · The paper itself

Abstract

We measured the accuracy of the urine test (RAPIRUN) for detection of Helicobacter pylori infection in Indonesia (Jakarta, Pontianak, and Jayapura) using histology confirmed by immunohistochemistry and/or culture as gold standards. We also used immunohistochemistry to identify CagA phenotype and analyzed H. pylori CagA diversity in Indonesia. The overall prevalence of H. pylori infection in 88 consecutive dyspeptic patients based on the urine test was 15.9% (14/88), 38.1% for patients in Jayapura that had higher prevalence of H. pylori infection than that in Jakarta (9.7%, P = 0.02) and Pontianak (8.3%, P = 0.006). Overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of RAPIRUN were 83.3%, 94.7%, 71.4%, 97.3%, and 93.2%, respectively. All of the H. pylori-positive patients were immunoreactive for anti-CagA antibody but not immunoreactive for East Asian specific anti-CagA antibody in all H. pylori-positive subjects. We confirmed the high accuracy of RAPIRUN in Indonesian population. In general, we found less virulent type of H. pylori in Indonesia, which partly explained the low incidence gastric cancer in Indonesia.

Indexed as

Helicobacter pyloriAdultAgedAged, 80 and overAntibodies, BacterialAntigens, BacterialBacterial ProteinsDyspepsiaFemaleHelicobacter InfectionsHumansIndonesiaMaleMiddle AgedAntibodies, BacterialAntigens, BacterialBacterial ProteinscagA protein, Helicobacter pylori

Identifiers

PMID26824034
PMCPMC4707432
OpenAlexW2211334547

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.