Evidence map›Paper›PMID 26823991›Full record

ArticleJournal of analytical & bioanalytical techniques2015

A Simple and Rapid LC-MS/MS Method for the Determination of BMCL26 a Novel Anti-Parasitic Agent in Rat Plasma.

Ramakrishna R Voggu, Xiang Zhou, Bin Su, Baochuan Guo

Open access · hybridAbstract read
In one paragraph

Article in Journal of analytical & bioanalytical techniques, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ramakrishna R VogguDepartment of Chemistry, Cleveland State University, USA.
Xiang ZhouDepartment of Chemistry, Cleveland State University, USA.
Bin SuDepartment of Chemistry, Cleveland State University, USA.
Baochuan GuoDepartment of Chemistry, Cleveland State University, USA.
Cleveland State University · US

Funding

Selective tubulin inhibitors with improved cell update for kinetoplastid infectionsR15AI103889 · NIAID · CLEVELAND STATE UNIVERSITY · PI SU, BIN · 2013 to 2016
$873k
NIAID NIH HHS R15 AI103889
6 · The paper itself

Abstract

BMCL26 is a potential drug derived from nimesulide, which has exhibited the substantial anti-parasitic activity in various cell lines. To conduct various pharmacological and toxicological properties of this drug, we developed and validated a rapid LC-MS/MS method for its quantification in accordance with the FDA guidelines. Protein precipitation with 0.1% formic acid in acetonitrile was used to extract the analytes along with the internal standard (JCC76) from rat plasma. It was found that the calibration curve of the method had an excellent linearity (r

Indexed as

Anti-parasiticBMCL26LC-MS/MSProtein precipitationRat plasma

Identifiers

PMID26823991
PMCPMC4727756
OpenAlexW2420785090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.