ArticleInternational journal of clinical and experimental pathology2015
Lobulated adenomyoepithelioma: a case report showing immunohistochemical profiles.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Malignant adenomyoepithelioma of the breast: Two case reports and review of the literature.World journal of clinical cases · 2021Article
- Immunohistochemical assessment of HRAS Q61R mutations in breast adenomyoepitheliomas.Histopathology · 2020Article
- Benign adenomyoepitelioma of the breast: Presentation of two rare cases and review of literature.International journal of surgery case reports · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lobulated adenomyoepithelioma of the breast is an extremely rare lesion, with hyperplasia of myoepithelial cells and glandular epithelial cells. We present a case of a 51-year-old woman with a small painless hard lump in each breast. The lesion in the left breast was an irregular solid mass, and the right breast showed a subareolar nodule with bloodstained nipple discharge. The final diagnosis was intraductal papillary carcinoma in the right breast and lobulated adenomyoepithelioma in the left breast. In the left breast lesion, histopathologic examination revealed multiple nodules composed of proliferative glandular epithelial cells and surrounding myoepithelial cells. Solid nests of clear or eosinophilic myoepithelial cells proliferated around compressed epithelial-lined space. Smaller satellite nodules were seen. Immunohistochemistry revealed myoepithelial cells were positive for P63, smooth muscle actin, calponin, 34βE12, CK5/6 and CK14, while glandular epithelial cells were positive for AE1/AE3 and CK7. Lobulated adenomyoepithelioma has a high chance of recurrence and malignant degeneration due to inadequate excision. Therefore, understanding of the pathological morphology and accurate diagnosis is important for surgical planning. Moreover, close follow-up is recommended for patients with lobulated adenomyoepithelioma despite the lesion being reported as benign.
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26823903PMC4713689W2255799729What OpenQuestion holds
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