Evidence map›Paper›PMID 26823831›Full record

ArticleInternational journal of clinical and experimental pathology2015

Implication of Reprimo and hMLH1 gene methylation in early diagnosis of gastric carcinoma.

Lianhua Liu, Xiaofeng Yang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. [Advances in serum biomarkers for early diagnosis of gastric cancer].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2019
    Review
  10. Review
  11. Journal of Cancer · 2018
    Article
  12. Article
  13. Role ofOncoTargets and therapy · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Feasibility of Plasma-MethylatedCancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lianhua LiuDepartment of Radiotherapy, Lin-Yi Cancer Hospital Linyi 276001, Shangdong, China.
Xiaofeng YangDepartment of Emergency Surgery, Lin-Yi People's Hospital Linyi 276001, Shandong, China.
Linyi People's Hospital · CNLinzhou Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation has been recently recognized as a novel tumor marker. This study investigated the methylation status of Reprimo and hMLH1 gene in both plasma and tissue samples from gastric cancer patients, in an attempt to investigate their diagnostic implications in gastric cancer. A total of 180 tissue and plasma samples (including 50 cases of gastric cancer, 50 dysplasia, 50 chronic atrophic gastritis with intestinal metaplasia and 30 normal controls) were collected for detecting DNA methylation status of Reprimo and hMLH1 genes using MSP method. Tissue protein expression levels were further tested by immunohistochemical (IHC) staining. The positive rate of DNA methylation rate was, in ascending sequence, gastritis tissue, dysplasia tissue and gastric carcinoma tissue. All those tissues had significantly elevated DNA methylation level compared to normal group (P < 0.05). Expression level of Reprimo and hMLH1 proteins were, however, decreased in pathological tissues compared to normal ones (P < 0.05). A significantly negative relationship existed between protein level and promoter region methylation level. The DNA methylation occurred in promoter regions of both Reprimo and hMLH1 genes depressed the protein expression, and may participate in the occurrence and progression and gastric cancer. The combined assay of serum Reprimo and hMLH1 DNA methylation levels thus had critical importance in the early diagnosis and gastric cancer.

Indexed as

DNA MethylationAdaptor Proteins, Signal TransducingAdultAgedBiomarkers, TumorCell Cycle ProteinsEarly Detection of CancerFemaleGene Expression Regulation, NeoplasticGlycoproteinsHumansImmunohistochemistryMaleMiddle AgedMutL Protein Homolog 1Nuclear ProteinsAdaptor Proteins, Signal TransducingBiomarkers, TumorCell Cycle ProteinsGlycoproteinsMLH1 protein, humanMutL Protein Homolog 1Nuclear ProteinsRPRM protein, humanDNA methylationearly tumor diagnosisgastric cancerhMLH1 genereprimo gene

Identifiers

PMID26823831
PMCPMC4713617
OpenAlexW2467330987

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.