ArticleInternational journal of clinical and experimental pathology2015
Expression of phosphorylated Akt and hTERT is associated with prognosis of epithelial ovarian carcinoma.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Research Progress in Prognostic Factors and Biomarkers of Ovarian Cancer.Journal of Cancer · 2021Review
- hERG1 is involved in the pathophysiological process and inhibited by berberine in SKOV3 cells.Oncology letters · 2019Article
- ShRNA-mediated silencing of hTERT promote apoptosis and senescence in human ovarian cancer cells.Translational cancer research · 2019Article
- Biologic Mechanisms Linked to Prognosis in Ovarian Cancer that May Be Affected by Aging.Journal of Cancer · 2019Review
- Functional evaluation of synthetic flavonoids and chalcones for potential antiviral and anticancer properties.Bioorganic & medicinal chemistry letters · 2017Article
- MicroRNA-153 regulated AKT1 expression and suppressed cell proliferation of epithelial ovarian cancer cells.International journal of clinical and experimental pathology · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of human telomere reverse transcriptase (hTERT) is associated with the tumorigenic role of Akt. We aimed to evaluate the significance of Akt phosphorylation and hTERT expression on the prognosis of epithelial ovarian cancer (EOC). Between 2005 and 2012, 92 EOC patients treated at the Seoul National University Hospital were included in this study. Paraffin-embedded sections from the tumors of EOC patients were stained with anti-hTERT and anti-phosphorylated Akt (pAkt) antibodies. Correlations of pAkt and hTERT expression with the clinicopathological factors were analyzed using SPSS software, version 17.0 (IBM, Chicago, IL, USA). In 92 EOC tissues, pAkt and hTERT were not associated with any clinicopathological factors. However, the disease-free survival rate of patients exhibiting coexpression of pAkt and hTERT was poor compared with that of the other patients (P = 0.013). Coexpression of pAkt and hTERT is a poor prognostic marker for EOC.
Indexed as
Identifiers
26823830PMC4713616W2432688603What OpenQuestion holds
Registered trials
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